Evidence map›Paper›PMID 41787287›Full record

ArticleBMC gastroenterology2026

Metabolic factors associated with colorectal neoplasms: a single center retrospective cross-sectional analysis of colonoscopy patients.

Junya Arai, Hiroaki Fujiwara, Tomonori Aoki, Ryota Niikura, Sozaburo Ihara, Nobumi Suzuki, Yosuke Tsuji, Yoku Hayakawa, Masato Kasuga, Mitsuhiro Fujishiro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Junya AraiDepartment of Gastroenterology, The Institute for Medical Science, Asahi Life Foundation, Bakuro-cho, Chuo-ku, Tokyo, 103-0002, Japan. ayayadejunyatoyomu@gmail.com.
Hiroaki FujiwaraDepartment of Gastroenterology, The Institute for Medical Science, Asahi Life Foundation, Bakuro-cho, Chuo-ku, Tokyo, 103-0002, Japan.
Tomonori AokiDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Ryota NiikuraDepartment of Gastroenterology, Graduate School of Medicine, Tokyo Medical University, Tokyo, Japan.
Sozaburo IharaDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Nobumi SuzukiDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Yosuke TsujiDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Yoku HayakawaDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Masato KasugaDepartment of Diabetes and Metabolism, The Institute of Medical Science, Asahi Life Foundation, Tokyo, Japan.
Mitsuhiro FujishiroDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. Colorectal neoplasms, including precursor lesions of CRC, are influenced by genetic and metabolic risk factors. However, many previous studies lacked detailed clinical information, such as laboratory data, abdominal ultrasonography, and computed tomography findings. This study aimed to examine the association between metabolic factors and colorectal neoplasms using detailed clinical and imaging data in a retrospective cross-sectional study.

methodsData from 1,916 patients who underwent colonoscopy between 2001 and 2021 were retrospectively evaluated. The primary outcome measure was the incidence of endoscopically diagnosed and pathologically confirmed colorectal neoplasms. Colorectal neoplasms include adenomas, sessile serrated lesions, and adenocarcinomas. The clinical factors associated with these neoplasms were also determined. The odds ratios (ORs) adjusted for age and sex were calculated.

resultsData from 781 patients with neoplasms and 54 patients with adenocarcinomas were analyzed. Male sex, age, waist circumference, laboratory data, including albumin, creatinine, high-density lipoprotein cholesterol, triglycerides, and HbA1c, non-alcoholic fatty liver disease fibrosis score, and abdominal ultrasound sonography findings of fatty liver were significantly associated with the incidence of any neoplasm. A multivariate analysis showed that male sex (aOR:1.54), age > 60 years (aOR:1.29), waist circumference > 85 cm (aOR:1.28), and fatty liver (aOR:1.31) were significantly associated with a higher odds of developing neoplasms.

conclusionsMale sex, old age, wide waist circumference, fatty liver, and high serum levels of several metabolic indicators are the risk factors for colorectal neoplasms. Colonoscopy is recommended for elderly men, particularly those with these metabolic factors.

Indexed as

AdenocarcinomaAdenomaColorectal NeoplasmsAgedAge FactorsColonoscopyCross-Sectional StudiesFatty LiverFemaleHumansIncidenceMaleMiddle AgedRetrospective StudiesRisk FactorsSex FactorsTriglyceridesColorectal neoplasmsFatty liverHigh-density lipoprotein cholesterolMaleMetabolic factorsUric acid

Identifiers

PMID41787287
PMCPMC13072499

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.