Evidence map›Paper›PMID 41787065›Full record

ArticleClinical pharmacology and therapeutics2026

Advancing Pharmacometrics in Africa: Insights and Perspectives From the 2025 Pharmacometrics Africa Conference.

Babatunde Ayodeji Adeagbo, Innocent Gerald Asiimwe, Linda Chaba, Aida N Kawuma, Francis Williams Ojara, Ochuko Maureen Orherhe, Simon Peter Asiimwe, Veshni Pillay-Fuentes Lorente, Sharon Sawe, Cassius M Phogole and 3 more

Abstract readConference Proceedings
In one paragraph

Article in Clinical pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Babatunde Ayodeji AdeagboDepartment of Pharmaceutical Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria.ORCID 0000-0002-6722-1970
Innocent Gerald AsiimweNovartis Pharmaceuticals UK Ltd, London, UK.ORCID 0000-0002-1196-1822
Linda ChabaStrathmore Institute of Mathematical Sciences, Strathmore University, Nairobi, Kenya.ORCID 0000-0002-4548-2563
Aida N KawumaInfectious Diseases Institute, Makerere University, Kampala, Uganda.ORCID 0000-0001-7975-0178
Francis Williams OjaraInfectious Diseases Institute, Makerere University, Kampala, Uganda.
Ochuko Maureen OrherheDepartment of Clinical Pharmacy and Pharmacy Administration, Obafemi Awolowo University, Ile-Ife, Nigeria.
Simon Peter AsiimweInfectious Diseases Institute, Makerere University, Kampala, Uganda.
Veshni Pillay-Fuentes LorenteDivision of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Sharon SaweDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0009-0003-7251-8546
Cassius M PhogoleDivision of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Catriona WaittInfectious Diseases Institute, Makerere University, Kampala, Uganda.ORCID 0000-0003-0134-5855
Samer MouksassiDepartment of Bioengineering and Therapeutic Sciences, School of Pharmacy, University of California, San Francisco, California, USA.ORCID 0000-0002-7152-6654
Goonaseelan Colin PillaiDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-5658-3837

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pharmacometrics (PMX) in Africa has transitioned from foundational capacity-building to job creation, scientific leadership, regulatory influence, and health innovation. To accelerate this progress, the 2025 Pharmacometrics Africa Conference (PMXAC-2025) convened key stakeholders to consolidate the continental PMX community, review progress in local capacity, and define priorities for African-led quantitative pharmacology and regulation. Held as a hybrid event in Kampala, Uganda, PMXAC-2025 featured plenary sessions, technical workshops, and poster presentations. A pre-conference nlmixr2 workshop strengthened open-source modeling expertise, while eight presentations and 32 posters facilitated discussions on capacity development, regulatory integration, and methodological innovation. The conference brought together 108 delegates, including 40 online participants from 14 countries (six African), reflecting strong global engagement. Regulatory representation (4.6%) demonstrated growing interdisciplinary collaboration. Sessions highlighted PMX as central to evidence-based healthcare, with applications in regulatory harmonization, patient-centered dosing, and equitable access. Presentations on model-based bioequivalence (MBBE), physiologically based pharmacokinetic (PBPK) modeling for safely extrapolating drug exposure in complex, understudied populations such as pregnant women and children, and model-based meta-analysis (MBMA) illustrated data-driven solutions for resource-limited settings. Emphasis on open-source tools reinforced technical equity, while career discussions promoted mentorship and cross-border collaboration. A closing panel outlined eight priorities for sustained progress, including funding, leadership, and integrated multi-sector partnerships. PMXAC-2025 signaled Africa's transition toward PMX self-reliance and innovation, uniting continental and diaspora experts, advancing open science, and setting a roadmap for sustainable, model-informed drug development across the continent. To sustain this momentum, establishing PMXAC-2025 as a regular annual event was strongly recommended.

Indexed as

PharmacokineticsAfricaHumansModels, StatisticalModels, Theoretical

Identifiers

PMID41787065
PMCPMC13083365

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.