ArticleBrain imaging and behavior2026
Alterations of white matter connectivity in alopecia areata patients.
Article in Brain imaging and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
To investigate the topological architecture of white matter structural networks in patients with alopecia areata (AA), we conducted a cross-sectional study involving 186 participants, including 102 AA patients and 84 age- and sex-matched healthy controls (HCs). All participants underwent diffusion tensor imaging (DTI) using a 3.0-T MRI scanner. Graph theoretical analysis was employed to quantify key topological properties of structural networks, encompassing both global and nodal metrics. Compared with HCs, AA patients exhibited significantly shortened characteristic path length (1.353 ± 0.026 vs. 1.366 ± 0.028, P = 0.001) as well as increased clustering coefficient (0.705 ± 0.016 vs. 0.698 ± 0.015, P = 0.003), global efficiency (0.738 ± 0.015 vs. 0.733 ± 0.015, P = 0.008), and local efficiency (0.852 ± 0.008 vs. 0.849 ± 0.008, P = 0.032), indicating enhanced global integration and functional segregation suggestive of hyper-connectivity. Additionally, nodal analysis showed that alterations in AA patients were mainly located in regions involved in emotion-cognitive regulation. Such network-level perturbations may reflect neurobiological adaptive responses underlying the high prevalence of neuropsychiatric comorbidities in AA, and thus hold promise as potential imaging biomarkers for evaluating central nervous system (CNS) involvement in this disease. Collectively, these findings advance our understanding of the neuropathophysiological mechanisms underlying CNS perturbations in AA from a network neuroscience framework.
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