Evidence map›Paper›PMID 41787031›Full record

ArticleDigestive diseases and sciences2026

Mutations in Exon 29 of Ring Finger Protein 213 Are Associated with Early-Onset Colorectal Cancer.

Enoch Xun Jiang, Giulio Quarta, Olivia Delau, Aasma Shaukat

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Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Enoch Xun JiangDivision of Gastroenterology, Department of Medicine, NYU Grossman School of Medicine, 240 East 38th Street, Floor 23, New York, NY, 10016, USA.ORCID http://orcid.org/0000-0002-5771-4405
Giulio QuartaGastroenterology Associates of New Jersey, Clifton, NJ, USA.ORCID http://orcid.org/0000-0002-3776-1618
Olivia DelauDivision of Gastroenterology, Department of Medicine, NYU Grossman School of Medicine, 240 East 38th Street, Floor 23, New York, NY, 10016, USA.
Aasma ShaukatDivision of Gastroenterology, Department of Medicine, NYU Grossman School of Medicine, 240 East 38th Street, Floor 23, New York, NY, 10016, USA. Aasma.shaukat@nyulangone.org.ORCID http://orcid.org/0000-0003-2446-8858

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsGrowing evidence suggests that the gut microbiome plays a role in carcinogenesis for early-onset colorectal cancer (EOCRC). The novel Ring Finger Protein 213 (RNF213) gene has broad antimicrobial properties. Our study aimed to compare RNF213 mutation rates in EOCRC and late-onset colorectal cancer using data from the cBioPortal for Cancer Genomics.

methodsAll participants from the cBioPortal with CRC samples that profiled the RNF213 gene were included. Multivariable logistic regression was used to assess the association between EOCRC and primary tumor RNF213 mutation. Cox proportional hazards models were used to evaluate the influence of RNF213 mutation on all-cause mortality risk. All tests were two-sided.

results1594 participants with CRC from six cohorts were included, of which 7.8% (N = 125) had EOCRC. Participants with EOCRC were more likely to have late-stage CRC (p < 0.001) and left-sided tumors (p < 0.001). Participants with a mutation in exon 29 of RNF213 had significantly increased odds of EOCRC diagnosis (

conclusionsPrimary tumor mutations in exon 29 of the RNF213 gene are associated with significantly increased odds of EOCRC diagnosis in a multicohort sample of participants with CRC. Future studies of germline and precancerous RNF213 mutations are needed to elucidate its possible role in EOCRC tumorigenesis.

Indexed as

Adenosine TriphosphatasesColorectal NeoplasmsMutationUbiquitin-Protein LigasesAgedAge of OnsetExonsFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedRisk FactorsAdenosine TriphosphatasesRNF213 protein, humanUbiquitin-Protein LigasesBiomarkercBioPortalEarly‐onset colorectal cancerMicrobiomeRisk factor

Identifiers

PMID41787031

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.