Observational studyEye (London, England)2026
Pigment loss and pseudo-albinism in Birdshot chorioretinitis.
Observational study in Eye (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A Dataset of Widefield Fundus Images From Patients With Birdshot Chorioretinitis and Matched Control.Scientific data · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo describe a rare phenotype of birdshot chorioretinitis (BSCR) characterised by diffuse retinal depigmentation and to evaluate its relationship with disease chronicity and visual outcomes.
methodsThis observational study included patients from the CO-BIRD cohort with ultra-widefield fundus imaging. Retinal depigmentation was graded using the albinism scale by Kruijt et al. (grades 0-3). Eyes with a grade ≥ 2 in at least one image were included. Disease activity and severity were assessed using best-corrected visual acuity (BCVA), vision-related quality of life (VFQ-25), visual field testing and multimodal imaging.
resultsAmong 1016 eyes (508 patients), 52 eyes (26 patients, 5.1%) had depigmentation grade ≥ 2; 22 eyes (2.2%) reached grade 3. Fifteen years after symptom onset, BCVA worse than 0.7 logMAR occurred in 42.1% of grade 3 versus 5.0% of grade 2 eyes (p = 0.014). VFQ-25 scores were similarly reduced in both groups. Grade 3 was associated with a lower risk of optic disc oedema (HR = 0.38; p = 0.028) and a non-significant reduction in macular oedema risk. Choroidal neovascularisation occurred only in grade 3 (40.9%). Grade 3 was linked to worse BCVA (p = 0.012), higher pattern standard deviation (p = 0.011), and a history of active disease. Compared with previously published CO-BIRD data, grade 3 showed faster BCVA decline (p = 0.044) and greater cumulative loss (p = 0.001).
conclusionDiffuse retinal depigmentation resembling albinism is an uncommon but severe expression of BSCR, indicative of chronic disease and associated with poorer visual outcomes.
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