ArticleScientific reports2026
Seroprevalence, isolation, comprehensive characterization, and pathogenicity of Clostridium perfringens strain from yak in Xizang, China.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Isolation, Genomic Evolution, and Pathogenicity ofAnimals : an open access journal from MDPI · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
Clostridium perfringens is an anaerobic, toxin-producing pathogen responsible for enteric and systemic disease in livestock, yet its ecology in high-altitude yaks remains poorly understood. We conducted a comprehensive investigation covering eight counties of the Xizang Autonomous Region between July 2021 and October 2024. Serological screening of 922 unvaccinated yaks revealed an individual-level antibody prevalence of 0.76% (95% CI: 0.4-1.6) and a herd-level prevalence of 25% (95% CI: 12.7-43.4). Multivariable logistic regression identified residence below 4000 m as the sole significant risk factor (adjusted OR = 8.75; 95%CI: 1.3-56.8; P = 0.04). From seven seropositive animals, one representative isolate CPTibet-Y1 was obtained and subjected to detailed phenotypic, genomic and virulence analyses. Phenotypic profiling confirmed classic biochemical traits of C. perfringens, while 16 S rRNA, Toxin gene PCR typing and whole-genome sequencing classified the strain as toxin type A, harboring Toxin gene cpa, but lacking cpb, etx, iap, cpe and netB. Antimicrobial resistance profiling revealed broad-spectrum resistance encompassing sulfonamides, lincosamides and fluoroquinolones, underpinned by six acquired resistance determinants. In a murine infection model, intraperitoneal challenge with 5 × 10
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