Evidence map›Paper›PMID 41786864›Full record

ArticleScientific reports2026

Reference intervals for peripheral blood neutrophil CD64 index and monocyte HLA-DR in healthy adults.

Liangjun Zhang, Yi Li, Huixiu Zhong, Jingyuan Huang, Minggang Yin

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PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Liangjun ZhangDepartment of Laboratory Medicine, Zigong First People's Hospital, Sichuan province, Zigong, China. 287448695@qq.com.
Yi LiDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Huixiu ZhongDepartment of Laboratory Medicine, Zigong First People's Hospital, Sichuan province, Zigong, China.
Jingyuan HuangDepartment of Laboratory Medicine, Zigong First People's Hospital, Sichuan province, Zigong, China.
Minggang YinDepartment of Laboratory Medicine, Zigong Fourth People's Hospital, Sichuan province, Zigong, China.

Funding

2024 Zigong high quality development of key research and development technology plan 2024GZL03Zigong Key Science and Technology Plan 2023YKYXT01
6 · The paper itself

Abstract

Neutrophil CD64 (nCD64) index and Monocyte HLA-DR (mHLADR) played an important role in the diagnosis of infection, however, reference intervals for these parameters in healthy adults remain insufficiently defined. This study aimed to established reference intervals for nCD64 index and mHLADR% in the peripheral blood from 285 healthy adults. All the subjects were grouped into subgroups according to sex (male and female) and age (20–51 years, 51–90 years). The analyses indicated age to be an important factor associated with changes in nCD64 index, which gradually increased from 20 to 90 years and showed a positive correlation with age (P < 0.0001). In contrast, no significant differences in mHLA-DR% were observed across gender or age groups (p > 0.05). Furthermore, no correlation was found between nCD64 index or mHLA-DR% and all the inflammatory derived indicators of blood routine (P > 0.05). In conclusion, the reference intervals established for the nCD64 index and mHLA-DR% in healthy adults may provide supportive information for monitoring immune status in the context of infectious diseases.

Indexed as

HLA-DR AntigensMonocytesNeutrophilsReceptors, IgGAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedReference ValuesYoung AdultHLA-DR AntigensReceptors, IgGHealthy adultsInfectious diseaseMonocyte HLA-DRNeutrophil CD64 indexReference intervals

Identifiers

PMID41786864
PMCPMC13079880

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.