ArticleScientific reports2026
Robustness of interstitial photodynamic therapy treatment planning under power and positional uncertainties in light delivery.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Optical-thermal modeling and treatment planning of ICG-enhanced interstitial photothermal therapy using cylindrical diffuser fibers.Lasers in medical science · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While computer simulations can accurately model light dose delivery in interstitial photodynamic therapy (iPDT), predicting individual clinical outcomes remains difficult. In addition to biological uncertainties, inaccuracies in light delivery must be considered. Using simulations on virtual brain tumour (glioblastoma) models, we analyze two sources of uncertainty: light source power variations of [Formula: see text], [Formula: see text], and [Formula: see text], and positional deviations during source insertion, modelled as angular errors producing up to [Formula: see text] displacement. Simulated outcomes show minimal impact from power uncertainty, even at worst-case [Formula: see text]: the percent difference between maximum and minimum [Formula: see text] does not exceed [Formula: see text], with tumour coverage only dropping from the targeted [Formula: see text] to [Formula: see text]. Using a new power-uncertainty-aware option in the PDT-SPACE planning tool improves the worst-case minimum coverage from [Formula: see text] to [Formula: see text], eliminating the risk of under-treating. Position uncertainty was simulated by discretizing the space and randomizing source placements, showing a larger negative effect. Power re-optimization on measured post-insertion positions restores tumour coverage to [Formula: see text], while PDT-SPACE source-position optimization reduces average healthy tissue damage by [Formula: see text]. Combining both yields the most robust performance and minimizes sensitivity to positional deviations, thereby limiting light-delivery errors in iPDT.
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