Evidence map›Paper›PMID 41786777›Full record

ArticleNPJ vaccines2026

Peripheral rotavirus-specific T-cell responses following monovalent oral rotavirus vaccine in infants.

Alexander R Nicols, Yesun Lee, Zion Congrave-Wilson, Minjun Kim, Wesley A Cheng, Jaycee Jumarang, Jocelyn Navarro, Rafaella Navarro, Yamile Rodriguez-Angeles, David Durand and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Alexander R NicolsDivision of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Yesun LeeDivision of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Zion Congrave-WilsonDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Minjun KimDivision of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Wesley A ChengDivision of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Jaycee JumarangDivision of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Jocelyn NavarroDivision of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Rafaella NavarroInstituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.
Yamile Rodriguez-AngelesInstituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.
David DurandInstituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.
Zackary W TaylorDivision of Pediatric Infectious Diseases, Kaiser Permanente, Los Angeles, CA, USA.
Ruth G De LeónDepartment of Sexual and Reproductive Health, Gorgas Memorial Institute for Health Studies, Panama City, Panama.
Theresa J OchoaInstituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.
Alessandro SetteCenter for Vaccine Innovation, La Jolla Institute for Immunology (LJI), La Jolla, CA, USA.
Ricardo da Silva AntunesCenter for Vaccine Innovation, La Jolla Institute for Immunology (LJI), La Jolla, CA, USA.
Pia S PannarajDivision of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA. ppannaraj@ucsd.edu.

Funding

Gut Microbial and Metabolic Mediators of Rotavirus Vaccine ResponseR01HD100542 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PANNARAJ, PIA S · 2020 to 2024
$3.3M
National Institute of Health/National Institute of Child Health and Human Development HD100542NICHD NIH HHS R01 HD100542
6 · The paper itself

Abstract

Despite evidence of varying vaccine effectiveness, T cell responses to rotavirus (RV) vaccines remain incompletely studied. To address this research gap, RV-specific T cells in the blood of infants pre- and post-monovalent RV vaccination (RV1) were analyzed for memory recall and functionality using RV-specific peptide pool stimulation. We find that RV vaccine elicits heterogenous responses with respect to cellular and humoral immunity. T cell responses to RV vaccine are detectable in the periphery, though poorly functional. Vaccination induces Th2-biased conventional effector memory and central memory CD4 + T cells, as suggested by chemokine receptor profiles, though the response wanes by 8 months post vaccination. The presence of preexisting immunity results in no significant increase in either RV-specific IgA or T cells after vaccination. Our data provides the first in-depth assessment of RV-specific T cell responses induced by vaccine, demonstrating patterns of negative and positive association with response that may play a role in protection against rotavirus disease.

Identifiers

PMID41786777
PMCPMC13083868

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.