ArticleNature communications2026
A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases.
Abstract read
In one paragraph
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Multi-omics-driven precision medicine.iMeta · 2026Review
- The gut microbiome-cardiometabolic axis: insights into obesity, type 2 diabetes, and hypertension.Frontiers in endocrinology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
75 authors.
Kanta Chechi *Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom. k.chechi@imperial.ac.uk.ORCID http://orcid.org/0000-0003-1929-4128
Rima Chakaroun *Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0001-9901-1815
Antonis Myridakis *Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom.ORCID http://orcid.org/0000-0003-1690-6651
Sofia K Forslund-Startceva *Experimental and Clinical Research Center, Charité-Universitätsmedizin & Max-Delbrück Center, Berlin, Germany.ORCID http://orcid.org/0000-0003-4285-6993
Sebastien Fromentin *Université Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France.
Trine NielsenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-2066-7895
Judith Aron-WisneswkySorbonne Université, Inserm, Nutrition and Obesities: Systemic Approach Research Group, Paris, France.
Eugeni BeldaSorbonne Université, Inserm, Nutrition and Obesities: Systemic Approach Research Group, Paris, France.
Edi PriftiSorbonne Université, Inserm, Nutrition and Obesities: Systemic Approach Research Group, Paris, France.ORCID http://orcid.org/0000-0001-8861-1305
Pierre Bel LassenSorbonne Université, Inserm, Nutrition and Obesities: Systemic Approach Research Group, Paris, France.
Gwen FalonyLaboratory of Molecular Bacteriology, KU Leuven, Leuven, Belgium.
Sara Vieira-SilvaLaboratory of Molecular Bacteriology, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-4616-7602
Julien ChillouxDivision of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom.ORCID http://orcid.org/0000-0002-0384-7317
Kazuhiro SonomuraLife Science Research Center, Technology Research Laboratory, Shimadzu Corporation, Kyoto, Japan.
Lesley HoylesDivision of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom.ORCID http://orcid.org/0000-0002-6418-342X
Laura Martinez-GiliDivision of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom.ORCID http://orcid.org/0000-0001-5271-9672
Francesco PallottiDivision of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom.ORCID http://orcid.org/0000-0001-6042-6474
Petros AndrikopoulosDivision of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom.ORCID http://orcid.org/0000-0002-1555-3498
Francesc Puig-CastellvíMETAB-OMICS UMR8199/1283 CNRS, INSERM, Institut Pasteur de Lille, Lille University Hospital, University of Lille, Lille, France.ORCID http://orcid.org/0000-0003-1064-9586
Romina Pacheco TapiaMETAB-OMICS UMR8199/1283 CNRS, INSERM, Institut Pasteur de Lille, Lille University Hospital, University of Lille, Lille, France.ORCID http://orcid.org/0000-0002-4694-3456
Inés Castro-DionicioMETAB-OMICS UMR8199/1283 CNRS, INSERM, Institut Pasteur de Lille, Lille University Hospital, University of Lille, Lille, France.ORCID http://orcid.org/0000-0003-4349-3477
Hugo RoumeUniversité Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France.
Nicolas PonsUniversité Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France.
Emmanuelle Le ChatelierUniversité Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France.ORCID http://orcid.org/0000-0002-2724-0536
Benoit QuinquisUniversité Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France.ORCID http://orcid.org/0000-0002-7573-969X
Nathalie GalleronUniversité Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France.
Magali BerlandUniversité Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France.ORCID http://orcid.org/0000-0002-6762-5350
Michael T OlanipekunDivision of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom.
Manyi JiaDivision of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom.ORCID http://orcid.org/0000-0001-9467-1494
Angelos ManoliasDivision of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom.
Bridget HolmesGlobal Nutrition Department, Danone Research, Palaiseau, France.
Solia AdriouchSorbonne Université, Inserm, Nutrition and Obesities: Systemic Approach Research Group, Paris, France.
Matthias BlüherHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0003-0208-2065
Luis Pedro CoelhoStructural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany.
Kévin Da SilvaUniversité Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France.
Pilar GalanNutritional Epidemiology Research Team (EREN), CRESS, Inserm, Bobigny, France.ORCID http://orcid.org/0000-0003-1706-3107
Boyang JiDepartment of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden.
Ana Luisa NevesDivision of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom.
Christine RouaultSorbonne Université, Inserm, Nutrition and Obesities: Systemic Approach Research Group, Paris, France.
Joe-Elie SalemAP-HP Pitié-Salpêtrière Hospital, Department of Pharmacology, Paris, France.ORCID http://orcid.org/0000-0002-0331-3307
Valentina TremaroliThe Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-9150-4233
Tue H HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5948-8993
Nadja B SøndertoftNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-6350-8117
Christian LewinterNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Helle K PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-9609-7377
MetaCardis Consortium
Peter D MarkDepartment of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Jens P GoetzeDepartment of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Lars KøberDepartment of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-6635-1466
Henrik VestergaardNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-3090-269X
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-8748-3831
Jean-Daniel ZuckerSorbonne Université, Inserm, Nutrition and Obesities: Systemic Approach Research Group, Paris, France.
Taka-Aki SatoLife Science Research Center, Technology Research Laboratory, Shimadzu Corporation, Kyoto, Japan.
Serge HercbergNutritional Epidemiology Research Team (EREN), CRESS, Inserm, Bobigny, France.ORCID http://orcid.org/0000-0002-3168-1350
Fredrik BäckhedThe Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Ivica LetunicBiobyte Solutions GmbH, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-3560-4288
Jean-Michel OppertAssistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Nutrition Department, Paris, France.
Jens NielsenDepartment of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-9955-6003
Jeroen RaesLaboratory of Molecular Bacteriology, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-1337-041X
Ioanna TzoulakiDepartment of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom.ORCID http://orcid.org/0000-0002-4275-9328
Abbas DehghanDepartment of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom.ORCID http://orcid.org/0000-0001-6403-016X
Verena ZuberDepartment of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom.ORCID http://orcid.org/0000-0001-9827-1877
Emmanuelle BouzigonUniversité Paris Cité, Inserm U1124, Paris, France.ORCID http://orcid.org/0000-0001-5756-4286
Mark LathropVictor Phillip Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, Canada.
Parminder RainaDepartment of Heath Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada.ORCID http://orcid.org/0000-0002-8107-3193
Philippe FroguelMETAB-OMICS UMR8199/1283 CNRS, INSERM, Institut Pasteur de Lille, Lille University Hospital, University of Lille, Lille, France.ORCID http://orcid.org/0000-0003-2972-0784
Fumihiko MatsudaCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Florence DemenaisUniversité Paris Cité, Inserm U1124, Paris, France.ORCID http://orcid.org/0000-0001-8361-0936
Dominique GauguierVictor Phillip Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, Canada.ORCID http://orcid.org/0000-0001-6156-9530
Michael StumvollHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0001-6225-8240
Peer BorkMax Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.ORCID http://orcid.org/0000-0002-2627-833X
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. oluf@sund.ku.dk.ORCID http://orcid.org/0000-0002-3321-3972
S Dusko EhrlichUniversité Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France. stanislav.ehrlich@ucl.ac.uk.
Karine ClémentSorbonne Université, Inserm, Nutrition and Obesities: Systemic Approach Research Group, Paris, France. karine.clement@inserm.fr.ORCID http://orcid.org/0000-0002-2489-3355
Marc-Emmanuel DumasDivision of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom. m.dumas@imperial.ac.uk.ORCID http://orcid.org/0000-0001-9523-7024
Funding
EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013)) HEALTH-F4-2012-305312
Abstract
Cardiovascular diseases (CVD) remain a major global health challenge. Early markers of disease initiation and progression are urgently needed. We, and others, have previously shown changes in the gut microbiome in association with metabolic and CVD. Here, we demonstrate that gut microbiome-related changes can be detected in association with subclinical variations in heart and kidney function. Markers related to gut microbial metabolism of aromatic amino acids, phenylalanine and tyrosine, associate with circulating pro-atrial natriuretic peptide and estimated glomerular filtration rate in a metabolically healthy European population. Observational and genetic evidence further identify microbiome-related metabolites as mediators of this gut microbiome-kidney axis, with their baseline levels associating with incident CVD in an external Canadian population. Altogether, our work suggests that the gut microbiome interacts with the cardiorenal axis and participates in an interorgan crosstalk affecting host physiology and risk of CVD.
Indexed as
Cardiovascular DiseasesGastrointestinal MicrobiomeHeartKidneyAtrial Natriuretic FactorBiomarkersCanadaFemaleGlomerular Filtration RateHumansMalePhenylalanineTyrosineAtrial Natriuretic FactorBiomarkersPhenylalanineTyrosine
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.