Evidence map›Paper›PMID 41786746›Full record

ArticleNature communications2026

USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion.

Giulio Collotta, Marco Gatti, Irina-Maria Ungureanu, Vanessa van Ackeren, Emilie Rannou, Francesca Vivalda, Diego Gomez Vieito, Keri M Fishwick, Christine von Aesch, Antonio Porro and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Ubiquitination and NOncology letters · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Giulio CollottaInstitute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-0661-1905
Marco GattiInstitute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-5307-0123
Irina-Maria UngureanuUK Dementia Research Institute, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Vanessa van AckerenInstitute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0009-0009-4222-9966
Emilie RannouDepartment of Plant and Microbial Biology, University of Zurich, Zurich, Switzerland.
Francesca VivaldaInstitute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0009-0008-5300-1505
Diego Gomez VieitoInstitute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.
Keri M FishwickInstitute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.
Christine von AeschInstitute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.
Antonio PorroInstitute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.
Kyra UngerleiderUK Dementia Research Institute, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Ailin HeidariStructural Genomics Consortium, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0009-0001-1941-409X
Raphaël GuéroisUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0001-5294-2858
Rachel J HardingStructural Genomics Consortium, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-1134-391X
Sylvain BischofDepartment of Plant and Microbial Biology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-2910-5132
Gabriel BalmusUK Dementia Research Institute, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK. gb318@cam.ac.uk.ORCID http://orcid.org/0000-0003-2872-4468
Alessandro A SartoriInstitute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland. sartori@imcr.uzh.ch.ORCID http://orcid.org/0000-0003-2770-0333

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 310030_208143Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 31003A_176161Worldwide Cancer Research 23-0355
6 · The paper itself

Abstract

Human FAN1 is a structure-specific endonuclease implicated in the repair of DNA interstrand crosslinks (ICLs) and the excision of extrahelical CAG repeats-whose pathological expansion underlies Huntington's disease (HD), a progressive and currently incurable neurodegenerative disorder. However, mechanisms of post-translational regulation of FAN1 are still largely unknown. Here, we identify the ubiquitin-specific protease 7 (USP7) as an interactor of FAN1. USP7 stabilizes FAN1 protein levels in a deubiquitination-dependent manner, preventing FAN1 from proteasomal degradation. Consequently, we demonstrate that USP7 depletion leads to reduced chromatin association of FAN1 and increased cellular hypersensitivity following ICL damage. Moreover, loss of USP7 accelerates CAG repeat expansion in an RPE-1 cell model stably expressing mutant huntingtin (mHTT) exon 1 containing 129 CAG repeats (RPE-1

Indexed as

DNA RepairEndodeoxyribonucleasesExodeoxyribonucleasesMultifunctional EnzymesTrinucleotide Repeat ExpansionUbiquitin-Specific Peptidase 7Cell LineChromatinDNA DamageGenomic InstabilityHEK293 CellsHumansHuntingtin ProteinHuntington DiseaseUbiquitinationChromatinEndodeoxyribonucleasesExodeoxyribonucleasesFAN1 protein, humanHTT protein, humanHuntingtin ProteinMultifunctional EnzymesUbiquitin-Specific Peptidase 7USP7 protein, human

Identifiers

PMID41786746
PMCPMC13086964

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.