ArticleNature communications2026
Integrated electrochemical porous solid electrolyte reactor and packed bed reactor for efficient synthesis of nylon-6 precursor.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The current production of cyclohexanone oxime (CyO), an essential precursor in the global nylon-6 industry, relies on processes that utilize toxic substrates and hazardous oxidizing agents. Here we present a continuous process and reactor design, with integrated electrochemical porous solid electrolyte reactor (PSER) and packed bed reactor (PBR), for an electrolyte-free, scalable, and efficient generation of high-purity CyO product from cyclohexanone (CyH), oxygen and ammonia. By electrochemically converting oxygen into high-purity hydrogen peroxide in a PSER, followed by a direct feeding into a downstream PBR for CyH ammoximation without any intermediate purification steps, we are able to obtain electrolyte-free CyO products. In an integrated 25-cm² PSER (six times larger than our previous design) and a titanium silicate-1 filled PBR system, we successfully demonstrate high CyO product selectivity of 97.2%, high yield of 93.6%, as well as high peroxide utilization efficiency of 96.3%. By operating the PSER under 125 mA/cm
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