Evidence map›Paper›PMID 41786602›Full record

ArticleGenome research2026

Scalable cell-specific coexpression networks for granular regulatory pattern discovery with NeighbourNet.

Yidi Deng, Jiadong Mao, Jarny Choi, Kim-Anh Lê Cao

Abstract read
In one paragraph

Article in Genome research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yidi DengMelbourne Integrative Genomics, School of Mathematics and Statistics, The University of Melbourne, Parkville, Victoria 3010, Australia.
Jiadong Mao *Melbourne Integrative Genomics, School of Mathematics and Statistics, The University of Melbourne, Parkville, Victoria 3010, Australia.ORCID 0000-0002-3818-1981
Jarny Choi *Bioinformatics and Cellular Genomics, St Vincent's Institute, Fitzroy, Victoria 3065, Australia.ORCID 0000-0002-7788-8867
Kim-Anh Lê Cao *Melbourne Integrative Genomics, School of Mathematics and Statistics, The University of Melbourne, Parkville, Victoria 3010, Australia; kimanh.lecao@unimelb.edu.au.ORCID 0000-0003-3923-1116

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene networks provide a fundamental framework for understanding the molecular mechanisms that govern gene expression. Advances in single-cell RNA sequencing (scRNA-seq) have enabled network inference at cellular resolution; however, most existing approaches rely on predefined clusters or cell states, implicitly assuming static regulatory programs and potentially missing subtle, dynamic variation in regulation across individual cells. To address these limitations, we introduce NeighbourNet (NNet), a method that constructs cell-specific coexpression networks. NNet first applies principal component analysis to embed gene expression into a low-dimensional space, followed by local regression within each cell's

Indexed as

Computational BiologyGene Regulatory NetworksSoftwareAlgorithmsAnimalsClustering AlgorithmsGene Expression ProfilingHumansPrincipal Component AnalysisSequence Analysis, RNASingle-Cell AnalysisSingle-Cell Gene Expression Analysis

Identifiers

PMID41786602
PMCPMC13138013

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.