ArticleThe Journal of biological chemistry2026
Mapping the temporality and structural impacts of modifications in Escherichia coli tRNAs.
Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Transfer RNAs (tRNAs) are essential components of the protein synthesis machinery. Their biogenesis is a highly regulated process that involves the incorporation of numerous post-transcriptional chemical modifications, essential for tRNA folding, cellular stability and function. The sequential process by which these modifications are introduced remains poorly characterized. Previous studies have suggested the existence of modification hierarchies, particularly in the anticodon-loop region, but also among tRNA core modifications. Here, aiming to understand the molecular mechanisms by which modifications are incorporated in a bacterial model organism, we employed a combination of NMR spectroscopy and biochemical methods to characterize the maturation process of several Escherichia coli tRNAs. By monitoring tRNA maturation in a time-resolved fashion by NMR, we observed a conserved temporal pattern in the incorporation of the Ψ55, T54, and m
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