Evidence map›Paper›PMID 41786041›Full record

ArticleVirus research2026

Shared genetic structure between COVID-19 and migraine: insights from large-scale genome-wide cross-trait analysis.

Xiangyu Wang, Jinniu Guo, Jinfeng Liu, Jinzhao Jiang, Yu Long, Ruohan Sun

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Article in Virus research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Xiangyu WangDepartment of Ultrasound, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, Heilongjiang Province, 150001, China.
Jinniu GuoDepartment of Neurology, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, Heilongjiang Province, 150001, China.
Jinfeng LiuDepartment of Neurology, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, Heilongjiang Province, 150001, China.
Jinzhao JiangDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, Heilongjiang Province, 150001, China.
Yu LongDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, Heilongjiang Province, 150001, China. Electronic address: yu.long@hrbmu.edu.cn.
Ruohan SunDepartment of Neurology, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, Heilongjiang Province, 150001, China. Electronic address: sunruohan0@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study assessed the genetic correlation and causal relationship between COVID-19 phenotypes and migraine.

methodsGenome-Wide Association Study‌ (GWAS) data of 13,465 migraine cases and 264,662 controls were obtained from FinnGen consortium. Four phenotypes from COVID-19 HGI were analyzed. Linkage disequilibrium score regression (LDSC) assessed genetic correlations. Pleiotropy analysis under composite null hypothesis (PLACO) identified pleiotropic genes/SNPs. MsigDB v6.2 was used for gene annotation, and multi-marker Analysis of GenoMic Annotation (MAGMA) analyzed pathway enrichment. Tissue-specific expression and immune cell-type heritability were examined. Bidirectional mendelian randomization (MR) tested causality.

resultsModerate genetic correlations were detected between COVID-19 phenotypes and migraine. Local heritability correlations were found between three COVID-19 phenotypes and migraine. PLACO detected 13 pleiotropic SNPs and 6 pleiotropic genes, enriched in mTOR and beta catenin pathways. Tissue and cell-type specific analyses indicated high expression in lung and cerebral cortex tissues, along with specific immune cells. MR detected no robust causal effects between COVID-19 phenotypes and migraine.

conclusionsCOVID-19 phenotypes and migraine shared genetic structures, though no causality was detected. Pleiotropic genes play key roles in the mTOR and beta catenin pathways, with tissue enrichment in lung, cerebral cortex, and specific immune cells, suggesting a potential mechanism for shared susceptibility.

Indexed as

COVID-19Migraine DisordersGenetic PleiotropyGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLinkage DisequilibriumMendelian Randomization AnalysisPhenotypePolymorphism, Single NucleotideSARS-CoV-2CausalityCOVID-19Genetic correlationMendelian randomizationMigraine

Identifiers

PMID41786041
PMCPMC13000529

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