ArticleScience (New York, N.Y.)2026
Single intramuscular injection of self-amplifying RNA of
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Article in Science (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- From RNA design to delivery: Computational strategies for functional RNA therapeutics.Bioactive materials · 2027Review
- Bioengineering strategies for improving the immunogenicity of mRNA vaccines.Signal transduction and targeted therapy · 2026Review
- Application of nanotherapy in cardiovascular diseases featuring novel pharmacological mechanisms and drug delivery strategies.Discover nano · 2026Review
- Alphavirus replicase and regulatory RNA elements in host interactions and viral vector engineering.Journal of virology · 2026Review
- Rare TruncatingGenes · 2026Article
- From Cardiomyocyte Proliferation to Regenerative Ecosystems.JACC. Basic to translational science · 2026Article
- Intrapericardially injected hydrogel loaded with stromal cell secretome microparticles improves post-infarction myocardial repair in pigs.European heart journal · 2026Article
- ANP produced from self-amplifying RNA improves cardiac function after MI.Nature reviews. Cardiology · 2026Article
- Targeting DYRKs in Cardiovascular Diseases: From Biological Mechanisms to Therapeutic Translation.International journal of molecular sciences · 2026Review
- Protein-Encoding Chemically Modified mRNAs for Musculoskeletal Tissue Regeneration and Repair.Journal of functional biomaterials · 2026Review
- Review
Corrections and comments
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Authors and funding
22 authors.
Kaiyue ZhangDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.ORCID 0000-0002-9906-9053
Hongyan TaoUniversity of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-1639-9074
Dashuai ZhuDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.ORCID 0000-0002-4645-5786
Zhang YueDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.ORCID 0000-0003-1254-6222
Shiqi HuDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Yiping WuDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Na YanDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.ORCID 0000-0003-1900-6405
Yilan HuDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.ORCID 0009-0003-3847-6602
Shuo LiuDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Mengrui LiuDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.ORCID 0009-0001-4823-0134
Torsten Peter VahlSeymour, Paul and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Lauren Sharan RanardSeymour, Paul and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-2305-156X
Xiao ChengDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.ORCID 0000-0001-8487-3412
Alexander RomanovInstitute of Comparative Medicine at Columbia University, New York, NY, USA.
Jiaming LiuDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Savannah Weihang ZhangDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Yuan LiDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.ORCID 0000-0002-1929-5465
Chao LuDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Ming ShenDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.ORCID 0000-0001-8354-9266
Andrew LewisUniversity of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-3714-6711
Ke HuangDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.ORCID 0000-0002-9355-7224
Ke ChengDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.ORCID 0000-0001-8053-7059
Funding
Harnessing Platelet-Endothelial Interactions for Stem Cell DeliveryR01HL144002 · NHLBI · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Ke Cheng · 2019 to 2026
$4.5MNovel surface-modified bioresorbable zinc-based stent materialsR01HL140562 · NHLBI · UNIVERSITY OF NORTH TEXAS · PI Ke Cheng, Donghui Zhu · 2018 to 2026
$4.3MModulating Exosome Cargos and Surfaces for Precision Heart RepairR01HL146153 · NHLBI · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Ke Cheng · 2019 to 2026
$4.2MDrug Delivery and Biomimetic Approaches for Optimal Stem Cell TherapyR01HL154154 · NHLBI · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI CHENG, KE · 2021 to 2024
$3.1MInhalable stem cell exosome therapy for cardiac injuryR01HL170612 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Ke Cheng · 2024 to 2026
$2.2MInhalation Delivery of Exosome and microRNA Therapy for Lung FibrosisR01HL164998 · NHLBI · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Dashuai Zhu · 2022 to 2026
$1.9MSorting high extracellular vesicle secretors for optimal cell therapyR01HL179818 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Ke Cheng, Dino Di Carlo · 2025 to 2026
$1.4MElastic exosome-releasing conductive patches for heart repairR01HL175960 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI Ke Cheng, Yi Hong · 2025 to 2026
$1.4MPericardial mRNA therapy for myocardial infarctionR01HL181161 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Dashuai Zhu · 2025 to 2026
$807kCell-drones: engineered stem cell nanovesicles as alternatives to exosomesR01HL175373 · NHLBI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Ke Huang · 2024 to 2026
$782kInhalable Extracellular Vesicles Engineering for Lung Cancer TreatmentK99CA304506 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Mengrui Liu · 2025 to 2026
$256kNCI NIH HHS K99 CA304506NHLBI NIH HHS R01 HL140562NHLBI NIH HHS R01 HL144002NHLBI NIH HHS R01 HL146153NHLBI NIH HHS R01 HL154154NHLBI NIH HHS R01 HL164998NHLBI NIH HHS R01 HL170612NHLBI NIH HHS R01 HL175373NHLBI NIH HHS R01 HL175960NHLBI NIH HHS R01 HL179818NHLBI NIH HHS R01 HL181161
Abstract
Self-amplifying RNA (saRNA) enables sustained protein expression from a single administration. In this study, we developed an intramuscular saRNA-lipid nanoparticle (saNppa-LNP) therapy encoding natriuretic peptide type A (
Indexed as
Atrial Natriuretic FactorGenetic TherapyMyocardial InfarctionNanoparticlesRNAAnimalsDisease Models, AnimalInjections, IntramuscularLiposomesMaleMiceMice, Inbred C57BLMyocytes, CardiacRegenerationSwineAtrial Natriuretic FactorLipid NanoparticlesLiposomesRNA
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.