Evidence map›Paper›PMID 41785318›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Reactivation of the silenced

Leonie I Weber, Lea E Timpen, Anna-Sophia Egger-Hörschinger, Philemon Schöpf, Nesin D Ayhan, David Demmel, Madlen Hotze, Yang Zhang, Mahdi Mehrabi, Kane Puglisi and 5 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Reactivation of the silencedProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Leonie I WeberInstitute of Biochemistry, Faculty of Chemistry and Pharmacy, University of Innsbruck, Innsbruck 6020, Austria.ORCID 0009-0002-8352-5402
Lea E TimpenInstitute of Biochemistry, Faculty of Chemistry and Pharmacy, University of Innsbruck, Innsbruck 6020, Austria.ORCID 0009-0003-3207-0230
Anna-Sophia Egger-HörschingerInstitute of Biochemistry, Faculty of Chemistry and Pharmacy, University of Innsbruck, Innsbruck 6020, Austria.ORCID 0000-0002-5204-7121
Philemon SchöpfInstitute of Biochemistry, Faculty of Chemistry and Pharmacy, University of Innsbruck, Innsbruck 6020, Austria.
Nesin D AyhanInstitute of Biochemistry, Faculty of Chemistry and Pharmacy, University of Innsbruck, Innsbruck 6020, Austria.ORCID 0009-0005-1028-9607
David DemmelInstitute of Biochemistry, Faculty of Chemistry and Pharmacy, University of Innsbruck, Innsbruck 6020, Austria.ORCID 0009-0006-8373-3198
Madlen HotzeInstitute of Biochemistry, Faculty of Chemistry and Pharmacy, University of Innsbruck, Innsbruck 6020, Austria.ORCID 0009-0001-1816-2089
Yang ZhangInstitute of Biochemistry, Faculty of Chemistry and Pharmacy, University of Innsbruck, Innsbruck 6020, Austria.
Mahdi MehrabiOtto Loewi Research Center, Division of Immunology, Medical University of Graz, Graz 8010, Austria.ORCID 0009-0009-9212-5946
Kane PuglisiInstitute of Biochemistry, Faculty of Chemistry and Pharmacy, University of Innsbruck, Innsbruck 6020, Austria.
Eduard StefanCenter for Molecular Biosciences, University of Innsbruck, Innsbruck 6020, Austria.ORCID 0000-0003-3650-4713
Nassim Ghaffari-Tabrizi-WizsyOtto Loewi Research Center, Division of Immunology, Medical University of Graz, Graz 8010, Austria.ORCID 0000-0001-6696-8717
José M Ramos-PittolInstitute of Biochemistry, Faculty of Chemistry and Pharmacy, University of Innsbruck, Innsbruck 6020, Austria.ORCID 0000-0003-3753-5394
Marcel KwiatkowskiInstitute of Biochemistry, Faculty of Chemistry and Pharmacy, University of Innsbruck, Innsbruck 6020, Austria.
Markus HartlInstitute of Biochemistry, Faculty of Chemistry and Pharmacy, University of Innsbruck, Innsbruck 6020, Austria.ORCID 0000-0001-7447-5920

Funding

Austrian Science Fund (FWF) P33662
6 · The paper itself

Abstract

Starting from human colon cancer cells showing aberrant WNT/β-catenin/TCF signaling, hyperactivated

Indexed as

Colorectal NeoplasmsNerve Tissue ProteinsRepressor ProteinsWnt Signaling PathwayAnimalsbeta CateninCell Line, TumorGene Expression Regulation, NeoplasticGene SilencingHumansIntracellular Signaling Peptides and ProteinsPromoter Regions, GeneticProto-Oncogene Proteins c-mycbeta CateninIntracellular Signaling Peptides and ProteinsMYC protein, humanNerve Tissue ProteinsNMI protein, humanProto-Oncogene Proteins c-mycRepressor ProteinsCRISPR, CRISPR-Casgene regulationTraf2 and Nck-interacting kinase (TNIK)tumor formationv-Myc avian myelocytomatosis viral oncogene homolog (MYC)

Identifiers

PMID41785318
PMCPMC12974518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.