Evidence map›Paper›PMID 41784955›Full record

ArticleACS chemical biology2026

Genome Mining-Driven Isolation of New Gromomycins and Insights into Their Mode of Action.

Dmytro Bratiichuk, Franziska Fries, Marc Stierhof, Leon Morguet, Josef Zapp, Mathias Müsken, Yuriy Rebets, Maksym Myronovskyi, Rolf Müller, Jennifer Herrmann and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dmytro BratiichukDepartment of Pharmaceutical Biotechnology, Saarland University, Bld. C2.3, 66123 Saarbrücken, Germany.ORCID 0009-0008-7272-5306
Franziska FriesHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University, 66123 Saarbrücken, Germany.
Marc StierhofDepartment of Pharmaceutical Biotechnology, Saarland University, Bld. C2.3, 66123 Saarbrücken, Germany.
Leon MorguetHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University, 66123 Saarbrücken, Germany.
Josef ZappDepartment of Pharmaceutical Biotechnology, Saarland University, Bld. C2.3, 66123 Saarbrücken, Germany.
Mathias MüskenHelmholtz Centre for Infection Research (HZI), 38124 Braunschweig, Germany.
Yuriy RebetsGerman-Ukrainian Core of Excellence in Natural Products Research (CENtR), Zelena st. 20, 79005 Lviv, Ukraine.
Maksym MyronovskyiDepartment of Pharmaceutical Biotechnology, Saarland University, Bld. C2.3, 66123 Saarbrücken, Germany.
Rolf MüllerHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University, 66123 Saarbrücken, Germany.ORCID 0000-0002-1042-5665
Jennifer HerrmannHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University, 66123 Saarbrücken, Germany.ORCID 0000-0003-3398-9938
Andriy LuzhetskyyDepartment of Pharmaceutical Biotechnology, Saarland University, Bld. C2.3, 66123 Saarbrücken, Germany.ORCID 0000-0001-6497-0047

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The growing threat of multidrug-resistant bacterial infections highlights the urgent need for antibiotics with novel mechanisms of action. Gromomycins, a newly identified class of triterpene antibiotics, exhibit potent activity against Gram-positive bacteria, including drug-resistant species, through a previously uncharacterized mode of action. Here, we report the discovery of a gromomycin-like biosynthetic gene cluster in the

Indexed as

Anti-Bacterial AgentsMicromonosporaceaeCell MembraneGenome, BacterialMicrobial Sensitivity TestsMultigene FamilyStaphylococcus aureusAnti-Bacterial Agents

Identifiers

PMID41784955
PMCPMC13010261

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.