ArticleEuropean journal of pain (London, England)2026
Differential Alterations in Offset Analgesia and Conditioned Pain Modulation in Fibromyalgia: Evidence for Distinct Central Dysregulation.
Article in European journal of pain (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundChronic pain often involves abnormalities in central pain processing. Two commonly used experimental methods for central pain modulation are conditioned pain modulation (CPM) and offset analgesia (OA). However, it is uncertain how similar the underlying processes they measure are. Here, we applied CPM and OA in patients with fibromyalgia, a model disease of central sensitization, to explore these questions further.
methodsFifty-four female participants (27 fibromyalgia patients and 27 healthy participants) completed the Fibromyalgia Impact Questionnaire (FIQ) and the McGill questionnaire and underwent CPM and OA in a randomised order.
resultsCPM and OA were positively correlated in healthy participants (R
conclusionsThis study is the first to show that OA, not just CPM, is correlated with clinical features in fibromyalgia patients and that these two paradigms are inversely correlated and differentially related to disease symptomatology in fibromyalgia patients. STATEMENT OF SIGNIFICANCE: This study is the first to demonstrate that conditioned pain modulation (CPM) and offset analgesia (OA) are inversely correlated in patients with fibromyalgia compared with healthy controls and show distinct associations with symptom severity. These findings reveal divergent mechanisms of central pain inhibition in chronic pain, highlighting the potential of both OA and CPM as novel markers for disease characterisation.
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