Evidence map›Paper›PMID 41784824›Full record

ReviewAnnals of hematology2026

Immune reconstruction after allogeneic hematopoietic stem cell transplantation: rules, mechanisms, and applications.

Chen-Mo Li, Qiu-Yi Wang, Zhi-Gang Chen, Cong-Cong Wang, Yu-Tong Xie, Lei Gao

Abstract readReview
In one paragraph

Review in Annals of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chen-Mo LiMedical Center of Hematology, State Key Laboratory of Trauma, Burn and Combined Injury, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Qiu-Yi WangMedical Center of Hematology, State Key Laboratory of Trauma, Burn and Combined Injury, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Zhi-Gang ChenMedical Center of Hematology, State Key Laboratory of Trauma, Burn and Combined Injury, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Cong-Cong WangMedical Center of Hematology, State Key Laboratory of Trauma, Burn and Combined Injury, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Yu-Tong XieMedical Center of Hematology, State Key Laboratory of Trauma, Burn and Combined Injury, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Lei GaoMedical Center of Hematology, State Key Laboratory of Trauma, Burn and Combined Injury, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China. gaolei7765@tmmu.edu.cn.

Funding

the National Natural Science Foundation of China No. 82170161
6 · The paper itself

Abstract

Immune reconstitution (IR) is a critical factor influencing the quality of life and long-term prognosis in hematopoietic stem cell transplant (HSCT) recipients. But delayed IR post-transplant may lead to infections and disease recurrence, while impaired reconstitution is closely associated with graft-versus-host disease (GVHD). To formulate strategies that promote immune recovery, it is crucial to understand the fundamental principles and influencing factors of IR. The emergence of technologies such as single-cell sequencing enables researchers to reveal the specific patterns and mechanisms of immune reconstitution under different conditions, which has given us a better understanding of immune reconstitution than before. Current evidence indicates that delayed IR is related to several aspects, mainly the strength of the conditioning regimen, the composition of the graft, and the occurrence of GVHD. This review summarizes the main characteristics of immune reconstitution after allogeneic hematopoietic stem cell transplantation, combined with the latest research progress Carefully explore the influencing factors of immune reconstitution and the existing monitoring methods.

Indexed as

Hematopoietic Stem Cell TransplantationImmune ReconstitutionGraft vs Host DiseaseHumansTransplantation ConditioningTransplantation, HomologousAllogeneic hematopoietic stem cell transplantationGraft versus host diseaseGraft versus leukemiaImmune reconstitution after transplantation

Identifiers

PMID41784824
PMCPMC12963273

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.