Evidence map›Paper›PMID 41784823›Full record

ArticleBrain structure & function2026

Diffusion tensor imaging of cerebellar peduncles and association tracts in a case of primary complete callosal agenesis.

Jordi D Martinez, Eric Mooshagian, Haley Wang, Katherine H Karlsgodt, Lucina Q Uddin, Jason S Nomi

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In one paragraph

Article in Brain structure & function, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jordi D MartinezUndergraduate Neurosciences Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA. jordim@stanford.edu.ORCID http://orcid.org/0009-0009-9323-2401
Eric MooshagianDepartment of Cognitive Science, University of California San Diego, La Jolla, San Diego, CA, USA.ORCID http://orcid.org/0000-0001-5998-8445
Haley WangDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-8042-8343
Katherine H KarlsgodtDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-3332-4231
Lucina Q UddinDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-2278-8962
Jason S NomiDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA. jnomi@mednet.ucla.edu.ORCID http://orcid.org/0000-0001-7129-3793

Funding

Cognitive and Neural Flexibility in AutismR01MH107549 · NIMH · UNIVERSITY OF MIAMI CORAL GABLES · PI UDDIN, LUCINA QAZI · 2015 to 2019
$2.4M
Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD116691NIMH NIH HHS R01MH107549
6 · The paper itself

Abstract

The corpus callosum is the largest white matter tract in the brain, connecting the left and right cerebral hemispheres. Callosal agenesis is a condition where this tract fails to form during neurodevelopment. Despite this, individuals with callosal agenesis can present as cognitively and behaviorally asymptomatic, retaining some alternate form of interhemispheric communication. Afferent and efferent pathways linking the cortex to the contralateral cerebellum, such as the corticopontocerebellar tract (CPCT) and dentatorubrothalamic tract (DRTT), could serve as compensatory routes in individuals with callosal agenesis, and thus display adaptive changes in white matter structure. To investigate this possibility, we examined a 9-year-old boy with complete callosal agenesis, who performed in line with his peers on IQ and social communication measures, and compared his cerebellar and association tractography to 12 age-matched controls. Diffusion tensor imaging (DTI) metrics were calculated for a whole-brain seed, the cerebellar peduncles, the pontine decussations, the arcuate fasciculus, and the uncinate fasciculus. Whole-brain metrics showed typical fractional anisotropy (FA) but increased mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) in the callosal agenesis child compared with controls. This pattern was also observed in the right superior cerebellar peduncle. Dorsal pontine fibers exhibited low FA and high RD values in callosal agenesis. The left uncinate and right arcuate fasciculi exhibited a similar pattern of low FA and high RD compared with controls. Overall, this case study characterizes microstructural differences in cerebellar and association tracts in a child with complete callosal agenesis and intact cognitive abilities.

Indexed as

Agenesis of Corpus CallosumCerebellumDiffusion Tensor ImagingChildCorpus CallosumHumansMaleNeural PathwaysWhite MatterCallosal agenesisCortico-cerebellar pathwaysDiffusion metricsDiffusion tensor imagingWhite matter microstructure

Identifiers

PMID41784823

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.