ArticleInternational ophthalmology2026
Retinal and choroidal microvascular alterations in ıdiopathic pulmonary fibrosis: an OCTA study.
Article in International ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate retinal and choroidal microvascular changes in patients with idiopathic pulmonary fibrosis (IPF) using optical coherence tomography angiography (OCTA), and to explore whether IPF, traditionally considered a pulmonary disease, also manifests in the ocular microcirculation.
methodsIn this cross-sectional case-control study, 82 IPF patients and 82 age-, sex-, and eye-side-matched healthy controls were enrolled. All participants underwent comprehensive ophthalmic examination and macular OCTA imaging using the RTVue XR Avanti device. Vessel density (VD), foveal avascular zone (FAZ) area and perimeter (PERIM), flow area, selected area, and perfusion density were assessed in the superficial and deep capillary plexuses, outer retina, and choriocapillaris.
resultsThe IPF group exhibited significantly lower superficial foveal vessel density (p = 0.030), reduced outer retina selected area (p = 0.010), and decreased choriocapillaris selected area (p = 0.003) compared to controls. No significant differences were observed in FAZ area or deep plexus vessel densities.
conclusionPatients with IPF demonstrate measurable microvascular alterations in both the superficial retina and choriocapillaris, supporting the concept of IPF as a systemic disease with extra-pulmonary vascular involvement. OCTA may serve as a non-invasive imaging biomarker for detecting systemic microangiopathy in fibrotic lung disease.
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