Observational studyActa neurologica Belgica2026
Genetic and therapeutic insights in musician's dystonia: a single-centre case series and narrative review.
Observational study in Acta neurologica Belgica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
3 authors.
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Abstract
backgroundMusician’s dystonia is a task-specific focal dystonia that severely impacts professional performance and quality of life. Literature combining clinical data and therapeutic outcomes remains limited.
objectivesTo describe the clinical characteristics, genetic findings, and treatment outcomes in a cohort of musicians with dystonia, and to contextualise these data within current evidence.
methodsThis prospective, monocentric observational study included 20 patients diagnosed with musician’s dystonia at a tertiary movement disorder centre (October 2023 – October 2025). Data collected included demographics, instrument type, dystonia phenomenology, targeted genetic testing, and treatments received. Outcomes were assessed both clinically and subjectively.
resultsThe cohort comprised 16 males and 4 females (mean age at onset: 38 years). Instruments included keyboards (40%), strings (35%), and wind instruments (25%). Two patients carried TOR1A variants. Botulinum toxin injections were performed in 15 cases, with partial improvement in 80%. Sensorimotor retraining was used in 10 patients. Career impact was substantial, with 30% reporting career termination.
conclusionsMusician’s dystonia is heterogeneous and often career-threatening. Our findings highlight the importance of early diagnosis, genetic screening in selected cases, and multimodal management combining botulinum toxin and rehabilitative approaches.
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