Evidence map›Paper›PMID 41784675›Full record

ReviewCancer causes & control : CCC2026

Breast cancer inequities: the intersectional role of social epidemiology and tumor biology.

Malalage Nicole Peiris, Aylin Dedeoglu, Ilze Smidt, Akiko Suzuki, Esther Rheinbay, Adrian Ilinski, Jiaji George Chen, Osasogie Imafidon, Christina Ennis, Kiana Mahdaviani and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer causes & control : CCC, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Malalage Nicole PeirisMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Aylin DedeogluMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ilze SmidtMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Akiko SuzukiMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Esther RheinbayMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Adrian IlinskiSection of Hematology and Medical Oncology, Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, MA, USA.
Jiaji George ChenSection of Hematology and Medical Oncology, Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, MA, USA.
Osasogie ImafidonSection of Hematology and Medical Oncology, Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, MA, USA.
Christina EnnisSection of Hematology and Medical Oncology, Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, MA, USA.
Kiana MahdavianiSection of Hematology and Medical Oncology, Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, MA, USA.
Ruben DriesSection of Hematology and Medical Oncology, Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, MA, USA.
Leif W EllisenMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Naomi Y KoPerlmutter Cancer Center, NYU Langone Health, NYU Grossman School of Medicine, 160 East 34th Street, 7th Floor, New York, NY, 10016, USA. naomi.ko@nyulangone.org.ORCID https://orcid.org/0000-0001-9689-9601

Funding

Subclonal heterogeneity and outcome disparities in Triple-Negative Breast Cancer among African AmericansR01CA248923 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI LEIF W ELLISEN, Naomi Yu Ko · 2022 to 2026
$3.6M
NCI NIH HHS R01 CA248923
6 · The paper itself

Abstract

Breast cancer disparities in outcomes remain a persistent challenge in the USA, with survival influenced by neighborhood context, access to resources, and the applicability of existing scientific evidence across populations. These disparities arise from complex, intersectional factors spanning social, structural, and biologic domains. While social determinants of health (SDOH) are strongly associated with breast cancer incidence and outcomes, the causality of biologic mechanisms underlying these associations remain incompletely understood. This review examines breast cancer disparities at the societal level and highlights emerging research that links social epidemiology with tumor biology, emphasizing the need for continued investigation using advanced genomic and epigenetic approaches to better understand and ultimately reduce inequities in breast cancer outcomes.

Indexed as

Breast NeoplasmsHealth Status DisparitiesFemaleHumansSocial Determinants of HealthSocioeconomic Disparities in HealthUnited StatesBreast CancerHealth EquityPrecision Oncology

Identifiers

PMID41784675
PMCPMC12963184

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.