Evidence map›Paper›PMID 41784603›Full record

ArticleAmerican journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics2026

Craniofacial growth percentile curves: A clinical tool from the Craniofacial Growth Consortium Study.

Heesoo Oh, Kevin M Middleton, Manish Valiathan, Dana L Duren, Kieran P McNulty, James A McNamara, Mark Hans, Richard J Sherwood

Abstract read
In one paragraph

Article in American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Heesoo OhDepartment of Orthodontics, University of the Pacific, Arthur A Dugoni School of Dentistry, San Francisco, Calif.
Kevin M MiddletonDivision of Biological Sciences, University of Missouri, Columbia, Mo.
Manish ValiathanDepartment of Orthodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio.
Dana L DurenDepartment of Orthopedic Surgery, University of Missouri School of Medicine, Columbia, Mo; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Mo.
Kieran P McNultyDepartment of Ecology, Evolution, and Behavior, University of Minnesota, Minneapolis, Minn.
James A McNamaraDepartment of Orthodontics and Pediatric Dentistry, School of Dentistry, The University of Michigan, Ann Arbor, Mich; Department of Cell and Developmental Biology, School of Medicine, The University of Michigan, Ann Arbor, Mich; Center for Human Growth and Development, The University of Michigan, Ann Arbor, Mich.
Mark HansDepartment of Orthodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio.
Richard J SherwoodDepartment of Orthopedic Surgery, University of Missouri School of Medicine, Columbia, Mo; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Mo. Electronic address: sherwoodrj@health.missouri.edu.

Funding

Craniofacial Growth Prediction in Different Facial TypesR01DE024732 · NIDCR · WRIGHT STATE UNIVERSITY · PI OH, HEESOO, SHERWOOD, RICHARD J · 2015 to 2019
$3.0M
NIDCR NIH HHS R01 DE024732
6 · The paper itself

Abstract

introductionThis study aimed to develop new cephalometric standards incorporating samples from across North America, focusing on creating sex-specific percentile growth curves for craniofacial cephalometric measures using the extensive longitudinal data from the Craniofacial Growth Consortium Study.

methodsThis study comprised 2,100 subjects (1,056 males and 1,044 females) with 17,290 lateral cephalometric radiographs, spanning ages of 2.5-31.3 years. Twenty-four linear cephalometric measurements were calculated, including traits from the basicranium, maxilla, and mandible. For each measurement, multilevel nonlinear growth models were used to estimate growth milestones by sex, percentile growth curves were created, and a web-interface tool was developed to facilitate the practical application of these growth curves.

resultsGrowth milestones, including age at peak growth velocity and peak growth velocity, were estimated for each sex using double logistic growth models. The timing of peak growth velocity varies across different regions of the craniofacial complex. Craniofacial growth percentile curves were created and cross-validated. A web interface tool was created to allow users to retrieve individual-specific percentile scores.

conclusionsThe developed percentile growth curves and web-based tool offer a robust framework for clinicians to assess individual growth patterns, identify deviations from normative growth, and estimate future growth potential, supporting more personalized treatment planning and timing.

Indexed as

CephalometryGrowth ChartsMaxillofacial DevelopmentSkullAdolescentChildChild, PreschoolFemaleHumansLongitudinal StudiesMaleReference Values

Identifiers

PMID41784603
PMCPMC13138386

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.