ArticleJournal of clinical microbiology2026
Poloxamer dilution as an on-demand alternative to agar dilution-based antimicrobial susceptibility testing.
Article in Journal of clinical microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Agar dilution is a reference susceptibility testing method uniquely or preferentially recommended for certain antimicrobials. However, the effort required to pour individual agar plates spanning a doubling dilution range precludes its practical implementation in hospital clinical laboratories. Here, we describe an on-demand replacement for agar dilution, specifically substituting Poloxamer 407 (also known as Pluronic F-127) for Bacto agar as the solidifying agent. Notably, 20% Poloxamer 407 solutions (e.g., with Mueller-Hinton broth) remain liquid at refrigerated temperatures but solidify upon warming, enabling facile setup of poloxamer dilution testing in Petri dish or microwell format. For fosfomycin susceptibility testing, poloxamer dilution and reference agar dilution showed excellent categorical agreement (CA) and essential agreement (EA) for IMPORTANCE: Accurate antibiotic susceptibility testing is essential for guiding treatment of bacterial infections. For the antibiotic fosfomycin, used to treat
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