Evidence map›Paper›PMID 41784352›Full record

ArticleeLife2026

Concatenated modular BK channel constructs reveal divergent stoichiometry in gating control by LRRC26 (γ1), pore, and selectivity filter.

Guanxing Chen, Qin Li, Kunal Shah, Jiusheng Yan

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Tuning the gate and the gear: The LRRC26 (γ1) subunit modulates intrinsic gating and voltage-sensor coupling of the BK channel.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Tuning the gate and the gear: The LRRC26 (bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Guanxing ChenDepartment of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, United States.
Qin LiDepartment of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, United States.
Kunal ShahDepartment of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, United States.ORCID https://orcid.org/0000-0002-4721-1169
Jiusheng YanDepartment of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, United States.ORCID https://orcid.org/0000-0002-6633-1799

Funding

BK channel regulation by auxiliary LRR proteinsR01NS078152 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI YAN, JIUSHENG · 2012 to 2022
$3.5M
Pore Gating Mechanisms of BK ChannelsR01GM127332 · NIGMS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ALDRICH, RICHARD, HORRIGAN, FRANK T · 2018 to 2021
$1.7M
NIGMS NIH HHS GM127332NIGMS NIH HHS R01 GM127332NINDS NIH HHS NS078152NINDS NIH HHS R01 NS078152
6 · The paper itself

Abstract

Big-conductance, Ca²

Indexed as

Ion Channel GatingLarge-Conductance Calcium-Activated Potassium ChannelsMembrane ProteinsAnimalsCalciumHumansNeoplasm ProteinsProtein SubunitsCalciumLarge-Conductance Calcium-Activated Potassium ChannelsLRRC26 protein, humanMembrane ProteinsNeoplasm ProteinsProtein SubunitsbiochemistryBK channelchemical biologyconcatemergatingLRRC26nonestoichiometry

Identifiers

PMID41784352
PMCPMC12962649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.