Evidence map›Paper›PMID 41784325›Full record

SynthesisAnnals of medicine2026

Efficacy and safety of allergen-specific immunotherapy for allergic asthma: a meta-analysis comparing sublingual and subcutaneous routes across allergen types and age groups.

Weimou Yin, Weitong Zeng, Yutong Li, Shiting Huang, Shoucheng Cen, Bangling Su, Ting Zhou, Xuejun Qin

Abstract readMeta-AnalysisComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Weimou YinDepartment of Respiratory and Critical Care Medicine, Liuzhou People's Hospital, Liuzhou, China.
Weitong ZengDepartment of Respiratory and Critical Care Medicine, Liuzhou People's Hospital, Liuzhou, China.
Yutong LiLiuzhou Key Laboratory for Diagnosis, Treatment and Research of Asthma and Chronic Obstructive Pulmonary Disease, Liuzhou, China.
Shiting HuangLiuzhou Key Laboratory for Diagnosis, Treatment and Research of Asthma and Chronic Obstructive Pulmonary Disease, Liuzhou, China.
Shoucheng CenLiuzhou Key Laboratory for Diagnosis, Treatment and Research of Asthma and Chronic Obstructive Pulmonary Disease, Liuzhou, China.
Bangling SuLiuzhou Key Laboratory for Diagnosis, Treatment and Research of Asthma and Chronic Obstructive Pulmonary Disease, Liuzhou, China.
Ting ZhouDepartment of Respiratory and Critical Care Medicine, Liuzhou People's Hospital, Liuzhou, China.
Xuejun QinDepartment of Respiratory and Critical Care Medicine, Liuzhou People's Hospital, Liuzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis meta-analysis aims to evaluate the efficacy and safety of allergen-specific immunotherapy (AIT) in treating allergic asthma.

methodsA comprehensive search across PubMed, Cochrane Library, Embase and Web of Science was conducted. Randomized controlled trials (RCTs) evaluating AIT for allergic asthma were included. Data analysis was performed using RevMan 5.3, with evaluations for heterogeneity and publication bias. Subgroup analyses were stratified based on different treatment type, duration, age and allergen type (house dust mites vs. grass pollen).

resultsA total of 28 RCTs were included in the meta-analysis. AIT significantly improved asthma symptoms (

conclusionAIT is effective in improving asthma symptoms and reducing medication use, with subcutaneous immunotherapy being more efficacious than sublingual immunotherapy. The effectiveness varies by allergen type, with no substantial differences across age groups and treatment durations.

Indexed as

AllergensAsthmaDesensitization, ImmunologicSublingual ImmunotherapyAdministration, SublingualAge FactorsAnimalsChildHumansInjections, SubcutaneousPoaceaePollenRandomized Controlled Trials as TopicTreatment OutcomeAllergensAllergen-specific immunotherapyallergic asthmameta-analysissubcutaneous immunotherapysublingual immunotherapy

Identifiers

PMID41784325
PMCPMC12964469

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.