ArticleEuropean journal of endocrinology2026
Cortisol assays across the physiologic spectrum: access immunoassay compared with LC-MS/MS.
Article in European journal of endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundImmunoassays for cortisol are commonly used to evaluate adrenal function, but their similarity to gold-standard liquid chromatography-tandem mass spectrometry (LC-MS/MS) has not been demonstrated across the physiologic spectrum of cortisol production.
methodsIn this cross-sectional study, 97 adults without known adrenal disease underwent measurements of serum cortisol in the morning, post-dexamethasone suppression, and post-cosyntropin stimulation. Samples were analyzed on the Access Cortisol immunoassay and by LC-MS/MS.
resultsThe assays showed good correlation across the physiologic spectrum, with close agreement at the lower end (mean bias -0.06 µg/dL [-1.7 nmol/L] post-dexamethasone suppression) and somewhat poorer agreement at the upper end of the physiologic spectrum (mean bias -1.68 µg/dL [-46.4 nmol/L] post-cosyntropin stimulation). Concordance using common interpretative cutoffs was good, with Cohen's κ = 0.93 for cortisol >10 µg/dL (275.9 nmol/L; morning), κ = 0.98 for cortisol <1.8 µg/dL (50 nmol/L; post-dexamethasone), and κ=0.89 for cortisol >14.5 µg/dL (400 nmol/L; post-cosyntropin).
conclusionsClinicians should be reassured that this immunoassay provides cortisol measurements similar to gold-standard LC-MS/MS across the physiologic continuum.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.