ArticleFrontiers in neurology
Serum alkaline phosphatase levels at admission are associated with unfavorable prognosis in acute ischemic stroke patients undergoing endovascular thrombectomy.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Limited data exist on the association between alkaline phosphatase (ALP) levels and outcomes in acute ischemic stroke patients undergoing endovascular thrombectomy. This study aimed to evaluate the relationship between serum ALP levels at admission and unfavorable prognosis following endovascular thrombectomy. Methods: This retrospective study included patients who underwent mechanical thrombectomy for acute ischemic stroke (AIS) within 24 h of symptom onset at the Affiliated Hospital of Xuzhou Medical University between October 2018 and May 2025. Blood samples were collected upon admission in the emergency room. Unfavorable prognosis was defined as a modified Rankin Scale score of 3-6 at 90 days. Logistic regression analyses were conducted to examine the relationship between ALP levels and unfavorable prognosis. Results: Of the 385 enrolled patients, 209 (54.3%) experienced an unfavorable prognosis. These patients exhibited significantly higher serum ALP levels (83.8 ± 29.5 U/L versus 76.1 ± 27.9 U/L; Conclusion: Our findings demonstrate a positive association between serum ALP levels at admission and unfavorable prognosis in patients with AIS who underwent endovascular thrombectomy.
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