ArticleFrontiers in neurology
The value of peripheral blood PLR, Lp-PLA2, MHR, SII, and HCY in assessing the rupture risk of small and medium-sized intracranial aneurysms.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: We aimed to investigate the relationship of peripheral blood platelet-to-lymphocyte ratio (PLR), lipoprotein-associated phospholipase A2 (Lp-PLA2), monocyte-to-high-density lipoprotein ratio (MHR), systemic immune-inflammation index (SII), and Homocysteine (HCY) with risk of rupture for small to medium-sized intracranial aneurysms, and examine their combined value as potential predictive markers. Methods: We conducted a retrospective analysis of clinical data from 80 patients with intracranial aneurysms who underwent endovascular embolization from January 2022 to January 2025. Patients were divided into a ruptured group ( Results: Levels of PLR, Lp-PLA2, MHR, SII, and HCY were significantly higher in ruptured cases, while SOD and IL-10 were significantly lower ( Conclusion: PLR, Lp-PLA2, MHR, SII, and HCY were associated with rupture status in small to medium-sized intracranial aneurysms. A combined multi-biomarker nomogram showed strong apparent discrimination; however, the incremental value beyond established clinical and morphological predictors and the generalizability of this model need confirmation in larger, preferably multicenter cohorts.
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