ArticleFrontiers in neurology
Analysis of treatment outcome variations in infantile epileptic spasms syndrome.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
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Abstract
Background: To explore the key factors influencing outcomes in children with infantile epileptic spasms syndrome (IESS) and to elucidate their interrelationships to provide insights for optimizing clinical practice. Methods: This is a retrospective, single-center design study, included children diagnosed with IESS at West China Second Hospital of Sichuan University from April 2019 to April 2024. Descriptive analyses were performed to evaluate genetic and non-genetic etiological subgroups, categorized as structural and unknown causes. Genetic testing results were compared across groups. Pearson correlation and logistic regression analyses were employed to examine differences in treatment efficacy and identify associated risk factors. Results: In this study, 128 children diagnosed with IESS were enrolled and evenly divided into gene-positive and gene-negative groups. The gene-positive group exhibited earlier seizure onset, with a higher prevalence of hypotonia and developmental regression compared to the gene-negative group. Within the gene-negative group, children were further categorized into structural abnormality and unknown causes subgroups, among which EEG hypsarrhythmia was more frequently observed in the structural abnormality subgroup. The gene-positive group showed significantly poorer responses to ACTH, vigabatrin, and other ASMs. ACTH combined with vigabatrin therapy improved outcomes in some of the children. The non-ACTH treatment group demonstrated superior EEG improvement outcomes when compared with the ACTH-treated group ( Conclusion: The prognosis for IESS remains challenging, with treatment responses closely tied to etiology. Children with genetic etiologies demonstrate poorer responses to ACTH and other ASMs. However, ACTH combination with vigabatrin may improve treatment outcomes in some cases. Our findings suggest that ACTH treatment may not exert a substantial influence on long-term EEG outcomes in children with IESS.
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