Evidence map›Paper›PMID 41783835›Full record

ArticlePhysics and imaging in radiation oncology2026

Treatment planning comparison of focused very high energy electron and volumetric modulated arc therapy.

Florian Amstutz, Chengchen Zhu, Werner Volken, Hannes A Loebner, Silvan Mueller, Sascha Frei, Jenny Bertholet, Peter Manser, Michael K Fix

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physics and imaging in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Florian AmstutzDivision of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Chengchen ZhuDivision of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Werner VolkenDivision of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Hannes A LoebnerDivision of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Silvan MuellerDivision of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Sascha FreiDivision of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Jenny BertholetDivision of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Peter ManserDivision of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Michael K FixDivision of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: Very high energy electron (VHEE) radiotherapy gained interest owing to technical advances and its potential for FLASH radiotherapy. Magnetically focused VHEE (fVHEE) beams showed promises in preliminary investigations in water phantoms. However, inverse treatment planning for fVHEE remains unexplored in clinically motivated scenarios. This study presented first inverse-optimized fVHEE treatment planning, permitting comparison to the current clinical benchmark, volumetric modulated arc therapy (VMAT), independent of FLASH considerations. Material and methods: Seven cases across five sites (brain, head and neck, lung, prostate, and femoral head) were investigated. fVHEE plans were generated using Monte Carlo-based beamlet dose calculations and in-house inverse optimization. Plans employed 250 MeV electrons focused via idealized magnetic lenses. Plan quality was compared regarding target coverage and organ-at-risk (OAR) sparing. Results: fVHEE achieved equivalent or improved target coverage in four sites, with V Conclusions: First results on inverse-optimized fVHEE planning are encouraging, particularly for lateralized targets or directionally isolated OARs. fVHEE demonstrates potential for selective dose sculpting, further comparison to VHEE is required to isolate fVHEE-specific benefits.

Indexed as

FLASHFocused beamsTreatment planningVery high energy electron radiotherapy (VHEE)

Identifiers

PMID41783835
PMCPMC12955155

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.