Evidence map›Paper›PMID 41783814›Full record

ArticleFrontiers in nutrition2026

Age- and sex-specific reference intervals and determinants of plasma vitamin B6 metabolites in healthy Chinese adults.

Yazhao Mei, Ziyuan Wang, Li Shen, Zhenlin Zhang, Hua Yue, Hao Zhang, Jiemei Gu, Weiwei Hu, Shanshan Li, Chao Gao and 5 more

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Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Yazhao Mei *Shanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ziyuan Wang *Shanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Li ShenClinical Research Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhenlin ZhangShanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hua YueShanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hao ZhangShanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jiemei GuShanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Weiwei HuShanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanshan LiShanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chao GaoShanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhe WeiShanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yang XuShanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jie WangMedical Examination Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Gao GaoMedical Examination Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chun WangShanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Reference intervals (RIs) for vitamin B6 biomarkers remain underexplored in Chinese adults. We aimed to establish age- and sex-specific RIs of pyridoxal 5'-phosphate (PLP), pyridoxal (PL), 4-pyridoxic acid (PA), and their ratios (PLP/PL, PLP/PA, and PAr), and to identify independent determinants of these markers. Methods: Vitamin B6 metabolites were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The distribution changes were illustrated by sex-stratified age percentile curves (P10/P50/P90). Robust 95% RIs (P2.5-P97.5) were obtained by sex and age (<50 vs. ≥50 years) using the Horn-Pesce method. Sex-stratified multivariable linear regression was conducted to identify the independent determinants of vitamin B6 biomarkers. Results: This study included a community-based sample of 367 healthy adults (197 males and 170 females) with a median age of 49.0 years (range 20.0-80.0 years). Females had higher PLP, PL and PLP/PA, and lower PAr than males (all Conclusion: We established population-specific, age- and sex-stratified RIs for vitamin B6 biomarkers in healthy Chinese adults, providing a baseline for clinical and laboratory assessment of vitamin B6 metabolism. We also found that ALP, albumin, renal function, and serum phosphorus were closely related to the vitamin B6 status in both males and females.

Indexed as

4-pyridoxic acidmultivariate linear regressionpyridoxalpyridoxal 5′-phosphatereference interval

Identifiers

PMID41783814
PMCPMC12954621

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.