ArticleInternational journal of women's health2026
Protocol-Specific Luteinizing Hormone Thresholds for IVF Pregnancy Outcomes: The Moderating Role of Age in a Retrospective Study of 217 Cycles.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Effect of basal LH levels on pregnancy outcome after IVF/ICSI fresh embryo transfer in patients of different ages: a retrospective study.Frontiers in endocrinology · 2026Article
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Authors and funding
5 authors.
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Abstract
Objective: To explore the impact of trigger-day luteinizing hormone (LH) levels on pregnancy outcomes in antagonist and long protocols during in vitro fertilization (IVF) and determine protocol-specific LH thresholds. Methods: This retrospective analysis covered 217 IVF/ICSI cycles from January 2023 to April 2024. The relationships between trigger-day LH levels and pregnancy outcomes in the two protocols were compared using ROC curves, multivariate logistic regression, and mediation models. Results: In the antagonist protocol, LH > 1.45 IU/L was linked to lower oocyte yield, reduced high-quality embryo rates, and a higher risk of clinical pregnancy failure (RR = 2.34, p = 0.006). In the long protocol, LH > 1.0 IU/L was associated with higher clinical pregnancy rates (OR = 2.61, p = 0.026), with 68% of the effect mediated by increased oocyte yield. Age ≤ 35 significantly enhanced these effects (three-way interaction OR = 6.55, p = 0.003). Conclusion: The antagonist and long protocols should adopt LH thresholds of 1.45 IU/L and 1.0 IU/L, respectively. Age is a key moderator, providing evidence for individualized IVF trigger strategies.
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