ArticleRSC advances2026
2-Pyridone-assisted palladium-catalyzed regioselective arylation of naphthamides.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 authors.
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Abstract
The 2-pyridone scaffold receives attention in medicinal chemistry due to its bioisostere properties, which significantly contributing to lipophilicity, solubility, metabolic stability, and drug off-target effects. In the present article, we report the 2-pyridone-assisted regioselective arylation of naphthamides. Using diversified naphthamides and aryl iodides, a wide variety of 2-pyridone-containing molecular scaffolds were synthesized in good yields, which could be potentially useful in medicinal chemistry.
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