Evidence map›Paper›PMID 41783658›Full record

ArticleLeukemia research reports2026

Acute liver failure and severe lactic acidosis as initial manifestations of primary intestinal diffuse large B-cell lymphoma: Case report.

Hideki Mori, Shiro Miura, Momoko Soeda, Yoshitaka Imaizumi

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PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia research reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hideki MoriDepartment of General Internal Medicine, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan.
Shiro MiuraDepartment of Pathology, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan.
Momoko SoedaDepartment of Pathology, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan.
Yoshitaka ImaizumiDepartment of Hematology, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diffuse large B-cell lymphoma (DLBCL) typically presents with lymphadenopathy or extranodal masses, but rarely, predominantly as scattered case reports, as acute liver failure (ALF) with severe lactic acidosis. We report a 79-year-old man who presented with fulminant ALF, leukemoid reaction, and extreme lactic acidosis. Despite intensive care, he rapidly progressed to multiorgan failure and died. Autopsy revealed primary intestinal DLBCL with diffuse hepatic infiltration. This case illustrates the diagnostic challenge in emergency settings and highlights the concept of a "metabolic catastrophe" characterized by ALF, leukemoid reaction, and lactic acidosis. Early recognition of these features should prompt consideration of invasive diagnostic procedures and suspicion for aggressive lymphoma.

Indexed as

Acute liver failureCase reportDiffuse large B-cell lymphomaLactic acidosisLeukemoid reaction

Identifiers

PMID41783658
PMCPMC12954184

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.