Evidence map›Paper›PMID 41783626›Full record

ArticleThe World Allergy Organization journal2026

Longitudinal observation of severe asthma comorbidities and oral corticosteroids use from SANI and ISAR registries.

Giuseppe Guida, Ghislaine Scelo, Dominic A Friston, Francesco Blasi, Enrico Heffler, Pierluigi Paggiaro, Victoria Carter, Marco Caminati, Fabio Luigi Massimo Ricciardolo, Gianenrico Senna and 3 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The World Allergy Organization journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06625216 (Observatory of Patients With Severe Asthma and Potential Eligible Patients for Treatment With Biological Drugs), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06625216 recruitingnot on this map

Observatory of Patients With Severe Asthma and Potential Eligible Patients for Treatment With Biological Drugs

TypeobservationalSponsorSocietà Italiana di Allergologia, Asma e Immunologia ClinicaRan2017 to 2037Enrolled5,000ConditionsSevere Asthma
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Giuseppe GuidaDepartment of Clinical and Biological Sciences, University of Turin, Turin, Italy.
Ghislaine SceloObservational and Pragmatic Research Institute, Singapore.
Dominic A FristonObservational and Pragmatic Research Institute, Singapore.
Francesco BlasiRespiratory Unit and Cystic Fibrosis Center, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy.
Enrico HefflerPersonalized Medicine, Asthma and Allergy Clinic, IRCCS Humanitas Research Hospital, Rozzano (MI), Italy.
Pierluigi PaggiaroDepartment of Surgery, Medicine, Molecular Biology and Critical Care, University of Pisa, Pisa, Italy.
Victoria CarterObservational and Pragmatic Research Institute, Singapore.
Marco CaminatiAllergy Unit and Asthma Center, Integrated Verona University Hospital, Verona, Italy.
Fabio Luigi Massimo RicciardoloDepartment of Clinical and Biological Sciences, University of Turin, Turin, Italy.
Gianenrico SennaAllergy Unit and Asthma Center, Integrated Verona University Hospital, Verona, Italy.
David B PriceObservational and Pragmatic Research Institute, Singapore.
Giorgio Walter CanonicaPersonalized Medicine, Asthma and Allergy Clinic, IRCCS Humanitas Research Hospital, Rozzano (MI), Italy.
SANI network

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The International Severe Asthma Registry (ISAR) reported a high rate of comorbidities differentially associated with clinical characteristics, biomarkers, and outcomes. Methods: We aimed to compare the prevalences of comorbidities between global (ISARWORLD) and ITALY-derived ISAR cohorts and to explore characteristics of severe asthma (SA) patients progressively enrolled into the Severe Asthma Network Italy (SANI) registry over 5 years. Results: T2-related SA comorbidities, including allergic rhinitis (AR), chronic rhinosinusitis (CRS) and nasal polyps (NPs) were more frequent ( Conclusion: Longitudinal observation of enrolment characteristics from the Italian SANI registry and comparison with ISAR highlight changes influenced not only by regional population traits but also by the attitude of clinicians, biologics availability and eligibility and the OCS stewardship campaign. Trial registration: The International Severe Asthma Registry (ISAR): EU PAS number EUPAS23651; Study ID 47596; registered April 16, 2018. Severe Asthma Network Italy (SANI): NCT number: NCT06625216. Retrospectively registered 2024-07-05.

Indexed as

ComorbiditiesLongitudinal observationOral corticosteroidsRegistrySevere asthma

Identifiers

PMID41783626
PMCPMC12955625

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.