Evidence map›Paper›PMID 41783596›Full record

ArticleApplied biological chemistry2026

Trex1 overexpression leads to longer lifespans and fragmented sleep in

Jeonghan Kim, Stephanie Mao, Yazmin L Serrano Negron, Shailesh Kumar, Fan Zhang, Hong Xu, Susan T Harbison, Myung K Kim, Jay H Chung

Abstract read
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In one paragraph

Article in Applied biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jeonghan KimDepartment of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, South Korea.ORCID 0000-0003-1695-9630
Stephanie MaoLaboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD USA.
Yazmin L Serrano NegronLaboratory of Systems Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD USA.
Shailesh KumarLaboratory of Systems Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD USA.
Fan ZhangLaboratory of Molecular Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD USA.
Hong XuLaboratory of Molecular Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD USA.
Susan T HarbisonLaboratory of Systems Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD USA.
Myung K KimLaboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD USA.
Jay H ChungLaboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three-prime repair exonuclease 1 (Trex1) prevents cytosolic DNA accumulation and immune activation, yet the physiological consequences of increased Trex1 expression in vivo remain unclear. In this study, we used Drosophila melanogaster, a model well suited for quantitative analyses of aging, sleep, and circadian rhythms, to generate flies that ubiquitously overexpress murine Trex1 under the Act5C-GAL4 driver, given that a clear Trex1 ortholog has not been identified in flies. Trex1 overexpression significantly extended the lifespan of male flies (40.55 ± 1.10 days in controls;

Indexed as

And agingCircadian rhythmLifespanSleepTrex1

Identifiers

PMID41783596
PMCPMC12953298

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.