ReviewFrontiers in cell and developmental biology2026
Epigenetic remodeling during early embryonic development.
Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Organelle Crosstalk and Metabolic Reprogramming in Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Implications.Cell biochemistry and function · 2026Review
- Glycine as a Metabolic Regulator of Reproductive Function in Livestock: From Gametes to Early Embryos.Animals : an open access journal from MDPI · 2026Review
- Review
- When Fertilization Is Not Enough: Maternal-Zygotic Transition as a Determinant of Embryo Competence in IVF.International journal of molecular sciences · 2026Review
- MLL3/4 methyltransferases regulate the differentiation of pluripotent stem cells through coordinating glycolysis and mitochondrial respiration.bioRxiv : the preprint server for biology · 2026Article
- Exit from totipotency in mammals: an epigenetic perspective.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammals, the fusion of sperm and oocyte gives rise to a totipotent zygote, which undergoes a series of cleavage divisions and differentiation events. During this process, the embryo transitions from totipotency to pluripotency, accompanied by extensive epigenetic reprogramming. With continuous innovation of low-input multi-omics technology and other methods, the relationship between epigenetic remodeling and embryonic development has been gradually revealed. This review synthesizes recent advances in our understanding of the dynamics of epigenetic reprogramming during early embryogenesis in mice and humans. It covers the remodeling of DNA methylation, histone modifications, chromatin accessibility, and three-dimensional chromatin architecture, with a particular focus on the dynamic features of histone modifications. The patterns of common histone modifications such as methylation, acetylation, and ubiquitination are elaborated. Furthermore, the review outlines both the emerging roles of metabolism-associated modifications such as crotonylation and lactylation in genomic targeting and transcriptional regulation, and the dynamic patterns of histone variant incorporation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.