Evidence map›Paper›PMID 41783563›Full record

ArticleMarine life science & technology2026

A hybrid assembly mechanism employs nonreducing polyketide synthase-like logic for partially reduced polyketide formation.

Xianyan Zhang, Chuanteng Ma, Ziguang Deng, Xingtao Ren, Kaijin Zhang, Wenxue Wang, Luning Zhou, Yongchun Zhu, Guojian Zhang, Qian Che and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine life science & technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xianyan Zhang *Key Laboratory of Marine Drugs Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003 China.
Chuanteng Ma *Key Laboratory of Marine Drugs Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003 China.
Ziguang DengKey Laboratory of Evolution & Marine Biodiversity Ministry of Education, Institute of Evolution & Marine Biodiversity, College of Marine Life Science, Ocean University of China, Qingdao, 266003 China.
Xingtao RenKey Laboratory of Marine Drugs Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003 China.
Kaijin ZhangKey Laboratory of Marine Drugs Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003 China.
Wenxue WangKey Laboratory of Marine Drugs Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003 China.
Luning ZhouKey Laboratory of Marine Drugs Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003 China.
Yongchun ZhuKey Laboratory of Marine Drugs Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003 China.
Guojian ZhangKey Laboratory of Marine Drugs Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003 China.
Qian CheKey Laboratory of Marine Drugs Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003 China.
Tianjiao ZhuKey Laboratory of Marine Drugs Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003 China.
Hongan LongKey Laboratory of Evolution & Marine Biodiversity Ministry of Education, Institute of Evolution & Marine Biodiversity, College of Marine Life Science, Ocean University of China, Qingdao, 266003 China.
Bo DongKey Laboratory of Evolution & Marine Biodiversity Ministry of Education, Institute of Evolution & Marine Biodiversity, College of Marine Life Science, Ocean University of China, Qingdao, 266003 China.
Dehai LiKey Laboratory of Marine Drugs Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003 China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fungal iterative type I polyketide synthases (iPKSs) are commonly classified into nonreducing (NR-), partially reducing (PR-), and highly reducing (HR-) polyketide synthases based on their assembly mechanisms and domain structures. These iPKSs have been considered functionally and evolutionarily distinct, characterized by clear boundaries. However, emerging genomic analyses suggest that the diversity of iPKSs in fungi is far from fully understood. Here, we describe the discovery and characterization of PbPKS1 from a marine-derived fungus Supplementary Information: The online version contains supplementary material available at 10.1007/s42995-025-00342-5.

Indexed as

Domain recombinationIterative polyketide synthases (iPKSs)Nonreducing PKS (NR-PKS)Partially reducing PKS (PR-PKS)Product template

Identifiers

PMID41783563
PMCPMC12953777

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.