ArticleFrontiers in microbiology2026
B-cell peptide epitopes as diagnostic targets for Q fever in sheep.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Cascade-driven dual-signal attenuation antifouling immunosensor for femtogram-level sensing for SCCA.Analytical and bioanalytical chemistry · 2026Article
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10 authors.
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Abstract
Introduction: Q fever, caused by Scientific goal: In this study, a combined proteomic and literature research approach was used to identify immunoreactive proteins and predict linear B-cell epitopes as alternative diagnostic targets. Methods: Total protein extracts of a Results: A total of 156 seroreactive proteins, including 51 previously reported antigens, were detected, among others, Com1, CBU_0482, and Mip. Although the selected 15 peptides showed a specific reaction with pooled sera, they showed limited diagnostic performance with an area under the curve (AUC) of 0.5-0.7 when using single serum samples ( Discussion: Although single peptides lacked discriminatory power, multi-epitope combinations reached acceptable accuracy and may be used as a complementary tool for commercial ELISAs. However, larger bioinformatic approaches and validation studies are required to identify specific peptides of high diagnostic accuracy.
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