Evidence map›Paper›PMID 41783489›Full record

ArticleACS applied nano materials2026

Optically Detected Magnetic Resonance Based Intracellular Thermometry Using Nanodiamonds Implanted in Adherent Cancer Cells.

John C Consiglio, Rostislav Boltyanskiy, Yuliya L Mindarava, Christian Laube, Wolfgang Knolle, Marjan Berishaj, Fedor Jelezko, Kayvan R Keshari

Abstract read
In one paragraph

Article in ACS applied nano materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Closing the Loop: High-Precision 3D Photofabrication in Living Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

John C ConsiglioCenter for Molecular Imaging and Bioengineering, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Rostislav BoltyanskiyCenter for Molecular Imaging and Bioengineering, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Yuliya L MindaravaInstitute for Quantum Optics, Ulm University, 89081 Ulm, Germany.ORCID https://orcid.org/0000-0003-3668-1672
Christian LaubeDepartment of Functional Surfaces, Leibniz Institute of Surface Engineering, Leipzig 04318, Germany.ORCID https://orcid.org/0000-0002-6285-6934
Wolfgang KnolleDepartment of Functional Surfaces, Leibniz Institute of Surface Engineering, Leipzig 04318, Germany.
Marjan BerishajDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Fedor JelezkoInstitute for Quantum Optics, Ulm University, 89081 Ulm, Germany.
Kayvan R KeshariCenter for Molecular Imaging and Bioengineering, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.ORCID https://orcid.org/0000-0002-5181-8035

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Intracellular temperature influences cell metabolism and the tumor microenvironment, but there is a lack of consensus on basic thermal properties of cells and a shortage of reliable measurement tools. We utilized nanodiamonds (NDs) containing fluorescent Nitrogen Vacancy centers (NVs) implanted in glioblastoma cells to measure intracellular temperature via Optically Detected Magnetic Resonance (ODMR) and used dual fluorescence and bright-field imaging to establish ND-mitochondria distances. Careful ND selection, improved curve fitting, and time averaging enable repeatable measurement of cellular responses. Upon mitochondrial uncoupling with 5 μM FCCP, we reproducibly observed ODMR shifts consistent with an ∼1.7 °C temperature increase.

Indexed as

glioblastomaIntracellular thermometrymetabolismnanodiamondsNV-centeroptically detected magnetic resonancequantum sensing

Identifiers

PMID41783489
PMCPMC12954747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.