ArticleClinical and translational radiation oncology2026
Oncological outcomes involving interventional radiotherapy (brachytherapy) on the primary lesion and surgery on the neck for squamous cell carcinomas of the nasal vestibule.
Article in Clinical and translational radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Squamous cell carcinoma of the nasal vestibule (SCC-NV) is an under-recognized often misclassified malignancy, also due to the lack of a specific ICD-O topographic code. Management remains controversial, particularly regarding the clinical staging and the optimal treatment of the primary lesion. The Italian Society of Otolaryngology recently proposed interventional radiotherapy (IRT - brachytherapy) on the primary lesion and surgery on the neck as a standard multimodal approach in these cases. Methods: We retrospectively analysed 81 patients with SCC-NV treated between 2012 and 2024 in three Italian centres. All patients received IRT for the primary lesion, neck dissection was performed in cN + cases. Tumours were staged using UICC/AJCC, Wang, and Rome classifications. Results: Two-year overall survival, disease-specific survival, local relapse-free survival, and regional relapse-free survival were 87%, 91%, 86%, and 90%, respectively. The Rome classification showed superior predictive value for local and regional control compared to UICC/AJCC and Wang. Conclusion: The bimodal approach has provided excellent oncological outcomes in SCC-NV. Accurate baseline staging, including PET-CT and US-guided FNAB, is essential. The Rome T classification appears superior to existing systems and may guide future staging revisions. These findings support recent recommendations from the Italian Society of Otolaryngology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.