Evidence map›Paper›PMID 41783369›Full record

ArticlebioRxiv : the preprint server for biology2025

Targeting Impaired Type I Interferon-IL-27 Signaling Rescues T Regulatory Cell Suppressive Function in Relapsing-Remitting Multiple Sclerosis.

Manal Elzoheiry, Maryam Seyedsadr, John Wrobel, Yan Wang, Sowmya Shree Gopal, Ezgi Kasimoglu, Paulien Baeten, Ibrahim Hamad, Mia Rose Gleason, Bieke Broux and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Manal ElzoheiryDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, USA.
Maryam SeyedsadrDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, USA.
John WrobelDepartment of Microbiology and Immunology, Linberger Comprehensive Cancer Center, UNC, NC, USA.
Yan WangDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, USA.
Sowmya Shree GopalDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, USA.
Ezgi KasimogluDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, USA.
Paulien BaetenDepartment of Immunology, Hasselt University, Hasselt, Belgium. University MS Center, Campus Diepenbeek, Belgium.
Ibrahim HamadDepartment of Immunology, Hasselt University, Hasselt, Belgium. University MS Center, Campus Diepenbeek, Belgium.
Mia Rose GleasonDepartment of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Bieke BrouxDepartment of Immunology, Hasselt University, Hasselt, Belgium. University MS Center, Campus Diepenbeek, Belgium.ORCID 0000-0001-8509-2415
Jenny TingDepartment of Microbiology and Immunology, Linberger Comprehensive Cancer Center, UNC, NC, USA.
Booki MinDepartment of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Silva Markovic-PleseDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, USA.

Funding

Intracellular Innate Immune Receptors in Cancer Suppression and ImmunotherapyR35CA232109 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TING, JENNY P · 2019 to 2025
$6.4M
Molecular and Functional Analysis of NLR Family MembersR01AI029564 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jenny P Ting · 1991 to 2026
$6.0M
The role of IL-27/Lag3 axis in regulating Foxp3+ regulatory T cell functionR01AI125247 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Booki Min · 2017 to 2026
$3.4M
Immunoregulatory effect of microparticle delivered STING agonist in the control of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS)R21AI154772 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI MARKOVIC-PLESE, SILVA · 2021 to 2022
$431k
NCI NIH HHS R35 CA232109NIAID NIH HHS R01 AI029564NIAID NIH HHS R01 AI125247NIAID NIH HHS R21 AI154772
6 · The paper itself

Abstract

T Regulatory T cells (Tregs) from patients with relapsing-remitting multiple sclerosis (RRMS) exhibit impaired suppressive function, yet the underlying molecular mechanisms remain elusive. Single-cell RNA sequencing (scRNAseq) of

Identifiers

PMID41783369
PMCPMC12954510

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.