ArticleJHEP reports : innovation in hepatology2026
Serpine1 as a potential therapeutic target in pyrrolidine alkaloids-induced hepatic sinusoidal obstruction syndrome.
Article in JHEP reports : innovation in hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
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Authors and funding
8 authors.
Funding
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Abstract
Background & Aims: Hepatic sinusoidal obstruction syndrome (HSOS) induced by pyrrolizidine alkaloids (PAs) is a life-threatening liver injury for which standardized chronic models are lacking. This study aimed to establish a clinically relevant chronic PA-HSOS murine model and to identify potential therapeutic targets. Methods: A 28-day model was developed using key alkaloids from Results: The model faithfully recapitulated human HSOS, characterized by elevated liver enzymes (ALT, 1.6-fold, Conclusions: This first chronic PA-HSOS murine model closely mirrors human disease and identifies Serpine1 as a critical therapeutic target. Targeting the Serpine1-p53 axis with TM5441 represents a promising strategy to mitigate endothelial injury in PA-HSOS. Impact and implications: This study establishes a chronic PA-HSOS (pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome) model that more accurately replicates human disease progression, thereby overcoming the limitations of previous acute models for mechanistic and therapeutic research. The researchers identify Serpine1 as a key regulatory target that could lead to new therapies for PA-HSOS by reducing endothelial senescence and inflammation. These findings provide clinicians and researchers with improved tools for studying drug-induced liver injury and a pathway for translating discoveries into clinical trials. The therapeutic compound TM5441 shows promise for reversing liver dysfunction and vascular damage, while the model itself may aid in the development of better diagnostic criteria and prevention strategies. Clinical trial number: Not applicable.
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