ArticleFrontiers in artificial intelligence2026
An efficient strategy for fine-tuning large language models.
Article in Frontiers in artificial intelligence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Large Language Models (LLMs) achieve strong performance on many Natural Language Processing tasks, but adapting them to domain-specific applications is resource-intensive due to the cost of curating task-specific datasets and the compute required for fine-tuning. This work proposes an end-to-end strategy for rapidly fine-tuning LLMs for domain-specific tasks when both data and compute are limited. Methods: The strategy uses Distilling Step-by-Step (DSS) for dataset development and model training, where a teacher model generates task labels and intermediate rationales via Chain-of-Thought prompting for a natural-language-to-Query-DSL structured generation task. Using the resulting supervision, we benchmark three fine-tuning modalities through hyperparameter sweeps: full-precision fine-tuning, Low-Rank Adaptation (LoRA), and Quantized LoRA (QLoRA). To isolate the effect of rationale supervision, we additionally conduct an ablation study comparing DSS training (label + rationale supervision) against a label-only configuration. Results: Across the evaluated configurations, DSS combined with full-precision fine-tuning yields the strongest overall performance. Under resource constraints, DSS with LoRA provides an effective performance-efficiency tradeoff, and DSS with QLoRA enables training under tighter GPU memory budgets while maintaining competitive performance. In the parameter-efficient regimes, an alpha-to-rank ratio of 4:1 provides a consistent balance of performance and compute consumption across the explored settings. Discussion: These findings support a practical process for resource-constrained domain adaptation: use DSS to efficiently construct datasets, then select the fine-tuning modality based on available compute (full-precision when feasible; LoRA or QLoRA when memory-limited). The proposed workflow offers a general guide for efficiently fine-tuning LLMs for domain-specific tasks with limited data availability.
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