Prevalence and Predictors of Osteoporosis Among Saudi Patients with Rheumatoid Arthritis: A Single-Center Cross-Sectional Study.

Purpose: Osteoporosis (OP), a common comorbidity in patients with rheumatoid arthritis (RA), is characterized by reduced bone mineral density (BMD) and an increased risk of fractures. The interplay between chronic inflammation, RA medications, and other contributing factors exacerbates bone loss. In this study, we sought to estimate the prevalence of OP and identify factors associated with OP in patients with RA. Patients and Methods: We conducted a retrospective cross-sectional study using medical record data from patients diagnosed with RA at rheumatology clinics. The collected data included demographic details, clinical history, disease activity scores, medication use, and BMD measurements. Statistical analyses were performed to assess the prevalence of and identify significant risk factors for OP in this cohort. Results: We included 173 Saudi patients with RA (mean age: 46.29 years; 154 women, 19 men) in the study. Mean age was significantly higher in the OP group than in the normal-BMD group. Disease duration was significantly associated with low BMD; 35.4% of patients in the normal-BMD group had disease duration <2 years, compared with only 4.3% in the OP group, whereas 50% of patients with OP had disease duration >10 years. Conclusion: OP affected 26.6% of patients with RA, indicating that bone fragility is common in this population. The discovery that advanced age and disease duration are major risk factors for high-risk groups emphasizes the importance of early screening and targeted preventive interventions.