ArticleSurgical neurology international2026
Early T2-weighted magnetic resonance imaging changes after microsurgical clipping of unruptured aneurysms: Biomarkers of corridor-related tissue impact.
Article in Surgical neurology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Long-term Cerebrovascular Risk after Microsurgical Clipping of Unruptured Anterior Circulation Aneurysms: Low Subarachnoid Hemorrhage Incidence and Persistent Stroke Susceptibility over 7,600 Patient-years.Neurologia medico-chirurgica · 2026Article
- Local Recurrence after Microsurgical Clipping of Unruptured Intracranial Aneurysms: Incidence, Timing, and Risk Factors over 20 Years.Neurologia medico-chirurgica · 2026Article
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Authors and funding
5 authors.
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Abstract
Background: Diffusion-weighted imaging (DWI) detects ischemic injury after microsurgical clipping of unruptured intracranial aneurysms (UIAs), yet non-ischemic parenchymal effects remain poorly characterized. This study evaluated early postoperative T2-weighted imaging (T2WI) abnormalities to characterize corridor-related tissue impact and identify anatomical determinants of non-ischemic parenchymal changes. Methods: This retrospective study analyzed 797 anterior circulation UIA clipping procedures performed by a single surgeon under uniform protocol. Early postoperative magnetic resonance imaging (day 4-5) and 12-month follow-up were obtained. T2WI hyperintensities without restricted diffusion were classified as non-ischemic parenchymal changes. Stratified analyses isolated the effects of aneurysm depth within trans-sylvian (TS) approaches and rectal gyrus separation within interhemispheric (IH) approaches. Multivariate regression identified independent predictors. Results: Non-ischemic T2WI changes occurred in 20.1% (160/797) of procedures. IH approaches showed significantly higher incidence (50.7%) than TS approaches (13.8%, Conclusion: Early postoperative T2WI abnormalities represent a distinct imaging signature of corridor-related tissue impact, strongly associated with approach depth and anatomy. Their reversibility indicates transient mechanical stress rather than permanent injury. T2WI serves as an objective biomarker complementing DWI-based assessment and may inform surgical quality monitoring and patient counseling.
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