Evidence map›Paper›PMID 41783152›Full record

ArticleJournal of inflammation research2026

Explores the Relationship Between Serum Pepsinogen Levels and Gastric Mucosal Changes in Relation to

Alhaji Osman Smith, Isaac O Smalle, Ann Marie Rhoda, Aminata Fofanah Jones, Mbaimba Koroma

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Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Alhaji Osman SmithDepartment of Internal Medicine, Expresscare Medical Clinic, Kenema, Eastern Province, Sierra Leone.
Isaac O SmalleMinistry of Health and Sanitation (MOHS), Government of Sierra Leone, Freetown, Sierra Leone.
Ann Marie RhodaDepartment of Public Health, Faculty of Health Sciences and Disaster Management, Eastern Technical University, Kenema, Eastern Province, Sierra Leone.
Aminata Fofanah JonesDepartment of Public Health, Faculty of Health Sciences and Disaster Management, Eastern Technical University, Kenema, Eastern Province, Sierra Leone.
Mbaimba KoromaDepartment of Internal Medicine, Expresscare Medical Clinic, Kenema, Eastern Province, Sierra Leone.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pepsinogen I and pepsinogen II are widely used as diagnostic markers in gastric mucosal diseases such as gastric atrophy and pangastritis, and in assessing the risk of progression to gastric cancer. This study assesses the relationship between serum pepsinogen levels and changes in the gastric mucosa and stomach lining, stratified by Methods: A total of 84 patients presenting with dyspeptic symptoms or indigestion were recruited for the study. The hallmark diagnostic criteria for atrophic gastritis are serum PGI < 70 ng/mL, and for pangastritis, serum PGII > 20 ng/mL. The serum Results: Our findings defined the diagnosis of serum Conclusion: A low PGI, high PGII, and a PGI/PGII ratio ≤ 3 Sensitive biomarkers to identify patients at risk of developing pangastritis and gastric precancerous lesions in the absence of endoscopic gastric mucosal biopsy.

Indexed as

atrophic gastritisHelicobacter pyloripangastritispepsinogenPGI/PGII ratio

Identifiers

PMID41783152
PMCPMC12955366

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